ID A0A3B3HU15_ORYLA Unreviewed; 700 AA.
AC A0A3B3HU15;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101172314 {ECO:0000313|Ensembl:ENSORLP00000035307.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000035307.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000035307.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035307.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000035307.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035307.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011483272.1; XM_011484970.1.
DR AlphaFoldDB; A0A3B3HU15; -.
DR Ensembl; ENSORLT00000046730.1; ENSORLP00000035307.1; ENSORLG00000004714.2.
DR GeneID; 101172314; -.
DR GeneTree; ENSGT01090000260076; -.
DR OrthoDB; 3994459at2759; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000004714; Expressed in sexually immature organism and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890:SF22; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..700
FT /note="Interleukin-1 receptor accessory protein-like 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017253801"
FT TRANSMEM 361..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 162..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 242..348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 404..560
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 662..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 80246 MW; 6B59AF35B2946ADA CRC64;
MKASIPHLIL LHAAVVQCLK VVSKRGSVEG CTDWSVDYLK YKVLLGEPVR VKCALFYGYI
RANYSHAQST GLSLMWYKSA GHGDFEEPIS FDGARMSKEE DSIWFRPAEL EDVGYYSCVL
RNSTYCMKVS MSLTVAENDT ELCYNSKMRF YEKAELSKGK DITCPGIEDY LQPGVDPQIV
WYKECKPKQW RDTIERRKDV LSIRDVREDD IGNYTCELPF GNFMVRRTTE LSVTAPVTDK
PPKILFPSEG QLSFIEMALG SPINLTCRAY FGYSGDASPL IYWMKGDKFI EDLDEERIHE
SEIKTVREHL GEQEVSISLT IDFLEESDLG NYSCYVENSH GRRQANIQLV KKAELMYTVE
LAGGLGAILL LLICLVTLYK CYRIELMLFY RNHFGSEDVD GDNKDYDAYL SYTKVDPDQW
SQETREEERF ALEILPDVLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP
SYVVRRGWSI FELETRLRNM LVTGEIKVIL IECAELRGIM NYQEVEALKH TIKMLTVIKW
RGPSSNKLNS KFWKQLLYEM PFKRMEPLSI SHEQVLDVSE QGPFGELQTV SAISMAAATS
TAMATAHPDL RSTFHNSCHT QMRQKHYYRS YDYDLPPSGT LPPLSSLGNQ HTYCNIPMTL
INGQRPQSKS PRQQSMEEGH GNNAMLPLLP RETSISSVIW
//
