ID A0A3B3HUX3_ORYLA Unreviewed; 1239 AA.
AC A0A3B3HUX3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cullin-associated and neddylation-dissociated 2 (putative) {ECO:0000313|Ensembl:ENSORLP00000035545.1};
GN Name=cand2 {ECO:0000313|Ensembl:ENSORLP00000035545.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000035545.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000035545.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035545.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000035545.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035545.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAND family.
CC {ECO:0000256|ARBA:ARBA00007657}.
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DR AlphaFoldDB; A0A3B3HUX3; -.
DR STRING; 8090.ENSORLP00000035545; -.
DR Ensembl; ENSORLT00000032519.1; ENSORLP00000035545.1; ENSORLG00000025804.1.
DR GeneTree; ENSGT00390000017740; -.
DR InParanoid; A0A3B3HUX3; -.
DR OrthoDB; 68829at2759; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000025804; Expressed in bone element and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696:SF2; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR12696; TIP120; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 49..87
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1050..1212
FT /note="TATA-binding protein interacting (TIP20)"
FT /evidence="ECO:0000259|Pfam:PF08623"
FT REGION 313..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..341
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1239 AA; 135577 MW; 16976BC2889B5069 CRC64;
MSNVSYHISN LLEKMTSTDK DFRFMATNDL MLELQKDSIK LDEDSERRVV AMLLKLLEDK
NGEVQNLAVK CLAPLVSKVK EPQVEAMVES LCSNMMSDKE QLRDISSMGL KAVITELPLS
SSGLTLTASV SKMITSQLIG ALGKQEDVAL QLEALDILSD MLGRLSGALV SFHGSLLSSL
LPQLTSPRMA VRKRSIMALG HLVPCCSPAL FSQLTEHLMT ELAKGPPTSV ARTYIQCLAT
ISREGGHRVG EHLQKVIPMV VKFTSVEDDE LREHCFQAFE AFIRRCPKEM SPHVATVTQL
CFKFMTYDPN YNYDGSEEEE DESMDVEDGD DEESDDEYSD DDDMSWKVRR SAVKCLEALI
STRLDLLLSF YSTICPALLA RFKEREENVR ADVFAAFSTL LRQSRVGSSH PGLIATDAVR
SGVREEEPVV TLLKKQVPGI VKVLHRQLKD KSIKSRQGCF GLLSELAHTV PGALEEHIPA
LVPGILFSLT DKSASSNMKI DALCFLHVLL ISHPPQAFQP HMQVLLPAVL ACVEDTFYKI
MSEALLVTQQ LLRVMRPQGQ TSTPGRFDPK PFIREVFSVT MKRLKATDID QEVKERAISC
MGHLVCHLGD HLGAELQGVL AIFLERLKNE ITRLSAVRTL SLIAASSLKI DLSSILDETL
SVLASFLRKN QRALKLSTLA CLTALVTHHA ASIKPAALEA MLNELPPLVD ESDMHTSQVS
IALLTCMSKA CPSSLAKISS SVLPGIFRLI HSPLLQGGAL AAILDFLQSL VLSKASSLGY
GQLMKALMEP FQNPPPESSA LHRQSYISAA RCVAALVSAS PKDSPATVAG LIQQVKNPGS
PESARVLALL SLGEVGRSGS LGGCKEVQGV ILEAFSSTSE EVKTAASCAL GGMAVGSLSD
YLPFVLKEIS AQPRRQYLLL HSLKDVISAS PACSLSPHVE SIWSLLFQHC ECQEEGSRNL
VAECLGKLTL VDPAVLLPRL KQQLRAGSPV VRGTVVTAVK FTIVDHPAPI DALLRDCMGD
FLKSLQDDDI TVRRVALVMF NSAAHNKPSL IRGLLGSVLP HLYRETQIRK DLIREVEMGP
FKHRVDDGLD VRKAAFECMY TLLDSCLDGL DVLQFLDHVE EGLKDHYDIR MLTFLMLARL
ASLSPAAVLQ RLDRLVEPLK ATCTTKVKAG SVKQEFEKQE ELRRSAMRAV AALLAVPEVE
RSPIMADFAN QIRSNADMAS IYQSVQGGDG GGAEGMDMS
//
