ID A0A3B3HV98_ORYLA Unreviewed; 784 AA.
AC A0A3B3HV98;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000035762.1};
GN Name=LOC101155805 {ECO:0000313|Ensembl:ENSORLP00000035762.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000035762.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000035762.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035762.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000035762.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035762.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR AlphaFoldDB; A0A3B3HV98; -.
DR Ensembl; ENSORLT00000034659.1; ENSORLP00000035762.1; ENSORLG00000006807.2.
DR GeneTree; ENSGT01060000248595; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000006807; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF114; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..753
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 764..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 472
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 784 AA; 89479 MW; CD29CEC287BC1450 CRC64;
MAEAHQAVAF QFTVTPEGID LRLSHQALSE IYLSGVRSWK KRIIRIKNSV ITGVYPASPS
SWLFVVIAIL ATMYTRSDPS MGIIAKIQEH LPVSQSMSSQ CQAVVSAVLF STMLWLLLIF
TMRLCLKQLL SYHRWMFEQH GKMSTTTKIW VALVRIFSGR KPLLYSYQGS LPNLPVPAIK
DTVKRYLESV RPLMNDGEYE RMTKLATEFE SSLGNRLQWY LKLKALWASN YVSDWWEEYV
YLRGRSPIMV NSNYYGMDFL YVTPTPIQAA RAGNSIHAFF LYRRKLNKEE IKPLLLRSTV
PCCSYQFERM FDSCRIPGSL TDTVQHWKDS DYVAVYHKGR YFRLRVYQAG RLLSPREIEF
QIQRILDDPA PPSKGEAKLG ALTAADRVSW AEARVKYFSS GINKRSLDVI ERAAFFVTLD
DEEQGTMRDD QPASLDNYAK SLLHGKCYDR WFDKSFSVIY YKNGKSGING EHSWADAPVV
AHVWEYVLAT DSFQLGYNEE GHCKGEVDAS LPQPQKLNWE ISPECEEQIS RSLAVAQALA
DDVDFHVLSF RDFGKGQIKK CKVSPDAFIQ MTLQLAYYRE RGTFCLTYEA SMTRLFREGR
TETVRSCTNE SSAFVRALEN GEPADVCRRL FRGASEKHQQ LYRMAMTGAG IDRHIFCLYV
VSKYLGLESP FLKEVLAEPW RLSTSQTSIQ QVELFDLANH PEYISCGGGF GPVADDGYGV
SYNFIGENVI NFHISCKHSC PSTDAHKFGD QIRKAVNDLL QLLSPNQKES SKTEESQPKV
KKEQ
//
