ID A0A3B3HVY5_ORYLA Unreviewed; 1245 AA.
AC A0A3B3HVY5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000035997.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000035997.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035997.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000035997.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000035997.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3HVY5; -.
DR STRING; 8090.ENSORLP00000035997; -.
DR Ensembl; ENSORLT00000038942.1; ENSORLP00000035997.1; ENSORLG00000025035.1.
DR GeneTree; ENSGT01100000263543; -.
DR InParanoid; A0A3B3HVY5; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000025035; Expressed in pharyngeal gill and 1 other cell type or tissue.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR31635:SF196; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31635; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 498..765
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT COILED 306..333
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1245 AA; 141731 MW; 8C2B7CBA1A2FE548 CRC64;
MNSLNIVSWN VRGLGSGPKR LKVLNHLNDL KADIALLQET HLSLSAGHLL CCSQYPVMYS
ASFNSKQRGV AVLINKNVTF THKDTVTDPE GRFVIINISI QNKDFCIASI YGPNVDDSSF
FHRFFTSLSA HSDSTIIIGG DVNLVLDPEL DRLSTAANQR TWQSASILKQ YMNDLGLCDA
WRSCHPNTKG FTFFSPVHHS HSRLDYLLVS NSLLKEIKSS NIHPIIISDH APVSVNISGE
ISIPSGSTWR FNTSLLKDQE FIEFFKKEWE TFLEFNNTSE ISPSILWEAA KAVMRGKIIS
YSTHKKRKEK ADLLELENKI KTLETAYAAS AQEHILGDLK NLKLQFNDII NKQTQFQIQR
LRLERYENSN KSGKFLANQL KINKEKSTIT SIMDQTGNIT HDPVKINNAF KDFYQNLYTP
QINPSEQSIN SFLNNVNLPK LNEDQITNLD SPLSLSEFHE ALSLMPNSKA PGPDGFPAEF
YKEFWEQLAP TFYKTVKFIN ESQSLPPNMN SANIILLLKP DKDPTSPSSY RPISLINADV
KIICKALAQR IEKVTPHIIH FDQTGFIKGR HSDDNVRRLV NIIDYATIKN QEMTILSLDA
EKAFDRVNWK FLIAALHKFG FGESFINWIK ILYHNPNASV RTNKQTSNRF FLGRGTRQGC
PLSPSLFAIF IEPLAAAIRQ NESIKGIKTK HSHHKISLYA DDILLFLSNI HSVNETATII
NEFSSISDYS INWNKSVLLP LNSNAEQGLT IPVKSGNIKY LGIYFSPKIS ELVQLNYTPL
LKNIQDDLSR WTNLPLSLMG KVATVKMKIL PKVNYLFSMI PTQPPLKWFK TLDSSISSFL
WNNKPARISL KTLKSAKSCG GLELPNFHNY FLANRLQYIL KWLKINPETN SWLDLEQALC
GKINLSDLPF ISQIVKKQDC FKSININATL TAWWELLKIS KSSIQPCKMT PIWNNPDILI
NKKIIHFPAW QAGGIKQLEH IIIDRRFITP QELQDKHGIY NFLEYQQLKS IITKKFKYRD
NDLKLPDVVT TLINFSMNKT LSKIYKLLCN LDNNISLPTT KWDADLSIST DESFWSELCL
NTFKMTKSPN MQLIHFKTLH RIYYTGQRMF KMGLSNSDIC QHCDSNLPDN YMHALWFCTP
VQALWQQVCA DLSVWLKVSI TASPSLCVLG DMSAIDVEGG LGSIIFITLC IAKKTILINW
KSKKNINISQ HRNLLLDHIS LEKMSAQGSS NFERIQFSGL PWLTP
//
