ID A0A3B3HXC2_ORYLA Unreviewed; 359 AA.
AC A0A3B3HXC2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Hypoxia inducible factor 1 subunit alpha inhibitor {ECO:0000313|Ensembl:ENSORLP00000036484.1};
GN Name=hif1an {ECO:0000313|Ensembl:ENSORLP00000036484.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000036484.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000036484.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036484.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000036484.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036484.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3HXC2; -.
DR STRING; 8090.ENSORLP00000036484; -.
DR Ensembl; ENSORLT00000045789.1; ENSORLP00000036484.1; ENSORLG00000006864.2.
DR GeneTree; ENSGT00940000157409; -.
DR InParanoid; A0A3B3HXC2; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000006864; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0036140; F:[protein]-asparagine 3-dioxygenase activity; IBA:GO_Central.
DR GO; GO:0071532; F:ankyrin repeat binding; IBA:GO_Central.
DR GO; GO:0036139; F:peptidyl-histidine dioxygenase activity; IBA:GO_Central.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IBA:GO_Central.
DR GO; GO:1901343; P:negative regulation of vasculature development; IEA:Ensembl.
DR GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 1.10.287.1010; Clavaminate synthase-like; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR027452; FIH-1_dom_II.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR PANTHER; PTHR12461:SF93; HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 143..313
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
SQ SEQUENCE 359 AA; 41487 MW; 90F685BD32244EF8 CRC64;
MAAATVVEAD PATSEGGAAF SGVQTRGWDE SQLRKYSFPT KPIPRLSHTD PRAEMLINNE
EPVVLTDTNL VYPALKWDIP YLLENIGNGD FSVYMSENHK FLYYDEKKMP NFENFVPKSQ
RMEMKFSEFV DKMHQTEETG GESRVYLQQT LNDTVGKKIV VDFLGFNWNW INKQQAKRNW
GQLTSNLLLV GMEGNVTPAH YDEQQNFFAQ IKGYKRCILF PPDQFECLYP YPVHHPCDRQ
SQVDFDNPDY EKFPNFQNTV GYEAVVGPGD VLYIPMYWWH HIESLLNGGV TITVNFWYKG
APTPKRIEYP LRAHQKVAIM RNIEKMLGEA LGDPHEVKLS QTFLLISVMF AHECHIVHF
//
