ID A0A3B3HYA7_ORYLA Unreviewed; 1436 AA.
AC A0A3B3HYA7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000036576.1};
GN Name=LOC111947114 {ECO:0000313|Ensembl:ENSORLP00000036576.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000036576.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000036576.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036576.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000036576.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036576.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR Ensembl; ENSORLT00000045147.1; ENSORLP00000036576.1; ENSORLG00000029674.1.
DR GeneTree; ENSGT01060000248608; -.
DR InParanoid; A0A3B3HYA7; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000029674; Expressed in mesonephros and 8 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 311..325
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 368..403
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 556..735
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1073..1232
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1374..1432
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 258..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1436 AA; 161513 MW; DF4B065D0817FB18 CRC64;
MTERTGPTPD PADPEGLQHA LSIQENLLTH QAEAITLLSS AQWDLFRRLD SITQFLSAST
SQHANSAAAA QDPDSVNKAT SVSADIPENV RLQPEPFYGN VDAFGGFLLQ CQLIFQQAPR
YYHSDHSKIS LIVNSLRSKA LQWAQAFLAS HPIAHLPYDS FIGEFRLVFD QPRKQEEAVR
RLLSLKQGNR PVSDHLIDFR ILAVEAGWPD SALKGIFYQS LNERIKDHLC SQPEADSFED
LVTAALRSDI RLRERFAEQK RKSPVNPSPP MHAVQPSNRE TLDNVPHEPM QIGHSKLSPE
ERDKRRDEGL CFYCGQAGHM VSDCRARLKL PSPPLDNRPR GGDAELIHSF KFLCVPVKLS
HKNLVFELEA LIDSGAEHSL IDQRLVQELS LPVEPLANPG LGGKQLTRIT KRTGPVLLLT
SGNHREYLQF FITHCPQTPI ILGFSWLQIH NPHIDWSSPR IANWSTYCLA NCLHSALPIT
NVPDSAQEDI DLSNVPACYH DLRTVFSKVK ASSLPPHRPY DCSIELLNGA PLPKGKLYKL
SGPEKTAMEN YIQEALSQGH IRPSSSPVGA GFFFVEKKDK TLRPCIDFRE LNQITVKDKY
SLPLIDSVFE SVQQAKIFTK LDLRNAYHLV RIREGDEWKT AFTTPLGHYE YLVMPFGLTN
APAVFQRLVN DVLRDFLNRF VFIYLDDILI YSSDSSQHKH HVRLVLERLL ANQLFVKAEK
CEFHVSTVPF LGYIIEAGNI RPDPAKIEAV AQWEIPQTRK KLQQFLGFAN FYRRFIRNYS
SIAAPLTQLT SINKTYSWNP AADSAFKKLK SLFVSAPILI QPDVTKQFIV EVDASDSGVG
AVLSQREESS GKLKPCAFFS RKLSQAEQNY DVGNRELLAI KLALEEWRHW LEGAEKPFIV
WTDHKNLAYL RSAKRLNSRQ ARWCLFFDRF HFTISYRPGS RNVKPDALSR KYSSSDSSSD
SSILPMSCFV GSLTWEIESK VQQAQGEIPA GTSCPSGTLY VPESLRSEVI AWGHTSRIAC
HGGVYRTIRL LKRRFFWPSL ERDVREYISA CSICARSKSS NRPPSGHLLP LSMPSRPWSH
IAVDFVTGLP PSQGHTVILT VIDRFSKAAQ FIPLPQLPSA METADALIHH VFRHHGIPSD
IVSDRGPQFT SQVWKAFCSA LGATVSLTSG YHPQANGQAE RANQELEAAL RCLAAQNQED
WSKYLVWVEY AHNSHSSTAT GISPFEASLG YSPPLFPSQE LDLAVPSVQL HLQRCRDIWL
QTRVALLRTK ESNCQIANRH RVVSPNYQPG QKVWLSSRNI PLQASSRKLA PKFIGPYTID
RVINPVCVKL RLPAALKVNP TFHVSQVKPV TESPLCPPSA SPPPARTIDG APAFTVDRIL
DVRRRGRGVQ FLVDWEGYGP EERSWISRSL ILDHTLIDDF YRARPDRRLG PPGGGR
//
