ID A0A3B3HZB6_ORYLA Unreviewed; 1275 AA.
AC A0A3B3HZB6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=si:ch211-1i11.3 {ECO:0000313|Ensembl:ENSORLP00000036931.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000036931.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000036931.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036931.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000036931.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036931.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000478};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.25; Evidence={ECO:0000256|ARBA:ARBA00000106};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR AlphaFoldDB; A0A3B3HZB6; -.
DR Ensembl; ENSORLT00000045928.1; ENSORLP00000036931.1; ENSORLG00000014582.2.
DR GeneTree; ENSGT00940000159398; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000014582; Expressed in animal zygote and 12 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046872; DRHyd-ASK.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF391; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20309; DRHyd-ASK; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 577..835
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 902..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1139..1166
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 606
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1275 AA; 144300 MW; BF7523EDE8C3236D CRC64;
MTLRCRSWAP AAARTEENLS LKCLKEACAD AHATLKTFSF ETVSLGTTDI LDSFYNADVA
VVQMSDTFCQ PSLFYHLGVR ESFCMTNNII LYCYKQDGDL QALKEQCGSY TFIPYMVSPQ
GKLIAWDSTI MTCIKEWMQP SLKLEPLLTP LVERLVHLLN NVHIQSSEYF RESIRHEIRI
ARERFSGPAL SEELGRIQQR LDSVDLLTPD IILNLLLSYR DIQDYDAMIK LVETLNNLPM
CMVARHQNIK FHYIFALNRR NHPGDRAKAL QEILPIVESG NNVASDVYCL CGRIYKDMFM
SSMFTDVPSR DRACFWYGKA FEMEPTLHSG INSVVLLMAA GHEFETSIEL RKIGVTISTL
LGRKGSLEKM THYWDVGFYL GANILVKEYR KVIEASEKLY RLKAPVWFVC SLMETYILYR
QFAKLPETRS PKQDTVDFWM ELLLQSSKPT ISTDCYPVLI LEPSKLFQPA IVSVSKEDES
RTVHLKHVTS VKKGLHQWTF PASAIRGVSA SKIDERSCFL YVHYNSDDFQ LCFPSETHCK
SFCELVNSLI QLAENPSQNR EHLSGGVLEF VYETNENGDK VVLGKGTYGV VYAGRDLSNQ
VRIAIKEIPE KDSTYSQPLH EEIALHKRLK HRNIVQYLGS VSQDGFIKIF MEEVPGGSLS
SLLRSKWGPL KDNEPTIIFY TKQVLEGLKY LHDNQIVHRD IKGDNVLINT YSGVLKISDF
GTSKRLAGIN PCTETFAGTL QYMAPEIIDQ GPRGYGKPAD IWSLGCTIIE MATGKTPFHE
LGSPQAAMFK VGMFKIHPKV PECMSDEAKG FIMSCFEPNP DNRATAAELL MDTFLKSPGK
KKLKVLQKLE SDDSINSADY QRSLSVPISI LVEDTDSYSG SVDMPSSLDL RKHKSVFQAN
EISESPPSTS GFLLKPNGSS VDMSSPASSE ENIGLFMLRK DSERRATLHR ILTDSLNHVV
SNIQQSLPQC DDRCLTADHI IKLVTCLRDN IRSPNRQQLT RGLLELRSTL LASGIPVNNL
QVVLFNFQDA VKKVLKQQQV KPHWMFALDN LLRQAVQDAI TVLLPELKIQ LQSSFEFEDT
PLEGQPADPD TPVVLAPDQL GEPADTLRAA TKKENLLTVD LSSPTHIILD GNCTLSEKLR
DLRIETRRLL SQLSEKEQEY QMLLRNSMRR KRQHIDALRK ETVAEDKELA SRKNSKPETK
ALVRWLKSIQ VDQDTIDKLL AHEFTLDCLL FMACREDLGY CGLRGGMLCR LWAAITAHRK
THLSTHNEMC EDTLL
//
