ID A0A3B3HZF5_ORYLA Unreviewed; 1728 AA.
AC A0A3B3HZF5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Signal induced proliferation associated 1 like 1 {ECO:0000313|Ensembl:ENSORLP00000036843.1};
GN Name=SIPA1L1 {ECO:0000313|Ensembl:ENSORLP00000036843.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000036843.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000036843.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036843.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000036843.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036843.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011488738.1; XM_011490436.1.
DR STRING; 8090.ENSORLP00000036843; -.
DR Ensembl; ENSORLT00000040373.1; ENSORLP00000036843.1; ENSORLG00000016799.2.
DR GeneTree; ENSGT00940000155944; -.
DR InParanoid; A0A3B3HZF5; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000001038; Chromosome 22.
DR Bgee; ENSORLG00000016799; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF10; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 586..803
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 942..1006
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 112..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1665..1706
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1505
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1728 AA; 188653 MW; 850B3506FBEF23FE CRC64;
MTSLKLPPMD HTVGGSIPAT NEFYTSHLRM VNGGAALTQV DNIHPPVTTG VPKMGVRARV
ADWPPRKDIP GPIWHPSIEA DVSAVPKSHV KLGPALSPQD SSMLRNIHNT LKSRTQVQPN
NYSSPVTRYL APGDQRSSAS RNPRQRRVRQ RSNSDMAVGE MEAGADSGEE WGSSPGSKFS
PLHREYGSTS SINQHGISGE SIFEMLKGYE GEKVDHRSPA PEKLGDIPHV GSREANLKAQ
EDEIDGHLLK PKDRDKPPKR RTKSETGGES IFRKLRNVHG DLDSTRGGSD AEDGRTEDPG
PRLKRWVCQK GFAHYDVQSL LFDLNEIIHL RQTAVKIKNT TTGASAAAVA SASSTLSSTH
SLPYSSPSGS QEELSSRGSP SLDSGDEQSN EMLLSCPCFR NEIGTDVNGR GRLGHHLFLG
GGTSSGTPVG EVNLYETSVS HYSNAGVSVL EGAREEDNTL LKKGKQYIVE HMDLGAYYYR
KFFYSRDHWN YFGIDEALGP VAVSLCREKL EDDKEHSQQY NYRIIFRTSE MTTLRGSILE
DAVPSTSKHG TSRGLPVKEV LEYLLPELDL SCLRQALNTP KVTEQLMKLD EQGLSFQVKV
GVMYCRAGQS TEEEMYNNET AGSAFEEFLE LLGEKVRLKG FTKYRAQLDT KTDSTGTHSL
YTSHKDYEIM FHVSTLLPYT PNNKQQLLRK RHIGNDIVTI VFQEPGAHPF TPRNIRSHFQ
HVFIIVRVHN PCSDKTCYSI AVTRSQDVPS FGPPIPKGVT FPKSSVFRDF LLAKIINAEK
AAYKSEKFGA MATRTRQEYL RDLAERHVTS TPVEPTSKFP FISLAHKRRE KLRPYSGAEL
RSLGAITWQV HAEDQVAGAE RECLLAISND FIILLDQEAK VVVFNCATRD VIGWSTGSPA
SMKIYYERGE SVSLRSINNN TEDFGEVVKR LELLTKGSQT TEMTLRRNAL GQLGFHVNFE
GIVAEVEPYG YAWQAGLRQG SRLVEICKVS VASLSHEQMI DLLRTSVTVK VVIIPPHDDS
TPRRGCSEIY HMPLVDYKNH KEGMPYELKF PFRPANSNGK WPRTSSSPQT RAAGTAGTLI
KAPPADLSER NSAAIPRSVS SDGRPLNPKR YSPGNDNYAL ACSIVMGHTL HNTSTPSNLP
YAETISSSHW RQKSMPDGFN NNCQSPASFV RQAAGDGVNG MKASSSTGVG WIRSGEGDLC
SRLGDKVSSD TGVSKVTIPR LQPSDQSSRV SPNKNTKADG PYSSSQSSSN TLSSNASSSA
HSDEKWYEVG SHSGVQSDLE LNGYLQGTST DSGIDASSLT ATQSSTASST AAFRAKEKVP
WEESVASSPG AKSASPPTPD APVVAACGSE IPTKSSAVYL GGPDGGSYSL GDAPSPSSSG
HSEGLVVQGE AAEGAAANMS QNLQSPGTKS FYPRQGATSK YLIGWKKPGG SVNSIEFAST
RKRHPSDGLL GGPPQLRANL RGCHSPHRQT AKSSLEEDLK KLITLDSPPP TTTEEKPPFP
GPPPSRRSLQ RTLSDESIYG GQRETSSSGP HETSDLLFTC STLPRSPTTR HGSTRRASHK
SLGDLSASQS SELEKEKKRQ QQQQQQDPSL MPLPDAGVDG PLDWAHLVDA AKAFEEQRLA
FLTAQEEDST AEAMAAAIPQ QAEPQAAPPR QPLPGETPAI LLGKVDQLES MVKALQEDLN
KEKDAKASLQ AQIQSLREDN QRLLEESYSA SAKLKKFTEW VFNTIDMN
//
