ID A0A3B3HZI3_ORYLA Unreviewed; 567 AA.
AC A0A3B3HZI3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=MYCL proto-oncogene, bHLH transcription factor b {ECO:0000313|Ensembl:ENSORLP00000036868.1};
GN Name=myclb {ECO:0000313|Ensembl:ENSORLP00000036868.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000036868.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000036868.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036868.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000036868.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000036868.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MAX.
CC {ECO:0000256|ARBA:ARBA00025872}.
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DR AlphaFoldDB; A0A3B3HZI3; -.
DR STRING; 8090.ENSORLP00000036868; -.
DR Ensembl; ENSORLT00000036868.1; ENSORLP00000036868.1; ENSORLG00000024045.1.
DR GeneTree; ENSGT00940000158613; -.
DR InParanoid; A0A3B3HZI3; -.
DR OrthoDB; 3039999at2759; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000024045; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11457; bHLHzip_L-Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF5; PROTEIN L-MYC-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 2.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 484..536
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 62730 MW; 2A787EDD9825D6BF CRC64;
MHNRQLAPPP RPHSAAVCKE SERSRIPPRA ASSWTETRRT HRPPQTSAPR EGGTEAPRGA
RGDVAALGPF NLWIYEDARG LPALSRQRQQ GVIHPTPFPA APMPGISSFI PCYENWDMDH
LDHYQHYFYD DPDEDFFKST APSEDIWKKF ELVPTPPMSP IRASEGSSKV GLLHPSLGDK
LEWVSQFLGQ EDEQQSDLPC KLAATSETFG NLSSIIIQDC MWSGFSAGQQ LERVVGEHCA
PCPGTAAKTA AVSSVAPSGK AQGVLPDTPA LSVLAADCVD PAAVLTFPLS GGCKKQVCSG
SESHTDSSDD EDKDEDEEEI DVVTVEHKQQ QQSKPRRLVN ARKPVTITVR ADPHDPGMKR
FHISIHQQQH NYAAPSPDTL TAPSEPPRKR VRQEALVSMT QPHQNSAYQQ PRLGHAPLNL
ENRKSQFSGV RSESPNLSAS SPTSSTWPSS PPCSSSSSHH PHSSPSKTPT HLSSPQSSDC
EDTDKRKAHN FLERKRRNDL RSRFLSLRDE IPGLADCPKT PKVAILTRAT EYLRQLHACE
RLKAQERKQL KTRQMQLLHK LAQLKRS
//
