ID A0A3B3I011_ORYLA Unreviewed; 1614 AA.
AC A0A3B3I011;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000037413.1};
GN Name=adgrb2 {ECO:0000313|Ensembl:ENSORLP00000037413.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000037413.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000037413.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037413.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000037413.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037413.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8090.ENSORLP00000037413; -.
DR Ensembl; ENSORLT00000026892.1; ENSORLP00000037413.1; ENSORLG00000024462.1.
DR Ensembl; ENSORLT00000045971.1; ENSORLP00000028985.1; ENSORLG00000024462.1.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000024462; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1614
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041083883"
FT TRANSMEM 863..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1081..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..554
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 861..1135
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1284..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1614 AA; 177235 MW; 8EB620382AEFA522 CRC64;
MNTAGGVCLS VLSSLLAVAG VLAAVSDLRL APLFALAEAA HGAADSSRAE GPPSPISPPC
SSLVTGVLYG SFSLRELFPS RTPGCSWSLE NPDPTKYSLY LRFARHPIIC QTHFPMLLSL
DHHSANQSCP LHLQTSRDQE VLDLCGSQTD SDRLYSFLQF DKNFVQLCLT RHQTADEPQV
TKELLEQRLV EVLLINNENS SQFTCGVLCR WFEECLRLDH KENQDQSDRD GCGMTQTGCV
CPNHNIVPPH IPLLPETPHS FSNGSLVPED CCVTELHSND AIAIAPRDVR QEQYDDEDLR
VKTQRPRSAD QPGVFQAQTG DPAAEEWSQW SVCSLTCGQG WQVRTRSCVS SPYGTLCSGA
LRETRMCNNT VSCPGEPGII TSVEGQWSEW GPWSRCSVTC NPGVQQRQRR CSASVHGWAE
CKGPHQESRE CANPSCSGGN WGNWNHWSLC SKTCDTGWQR RFRMCEDTGP QGYPCDGSAE
EVRSCNEKKC PAPHEICKDE HLLSMSWKRA SAGETVYNKC PTNTSGSASR RCMLDNNGVA
FWGPPSFARC VSLEFRLLHL SLREHLAKGQ RTLAGEGMSQ IVRSLLELLQ RRSYYSGDLL
FSTEILRNVT DTFKRATYIP APDDVQKFFQ VVSHMLDLEN LEKWEDAHQV APGAALLMRI
LEDFIHLIGE AQKPFQSFLV VTNNLMVTIQ REPVSAVSSD INFPMKGRRG MKDWARTSED
KLYIPKKVFT SPTEEPESET TMYYVIGAIL YRTLGLILPA PIPPAVINSK ILTVTVRPEP
QLSEPMVELE LSPLINGTSD AECIVWDYGN PEAGAENWAT EGCQTLASNT VHTKCRCSRI
SSYAVLAQQA KDPDMGPTSM PSVPLMVGCG VSCTALLILL LIYAAFWRYI RSERSIILVN
FCFSILASNL LILAGQSQTI SKGLCAVTAA FLHFFFLASF CWVLTEAWQS YLAVIGKTRS
RIIRKRFLCL GWGLPALVVA VSVGFTRARG YGTASYCWLS LEGGLLYAFV GPAAVIVLVN
MLIGIVVFNK LMSRDGISDK SKKHRAGVPA EARSRLLLKC SKCGVISSTA MSSSTASSAM
ASLWSSCVVL PLLALTWMSA VLAITDRRST LFQVLFAVFD SVQGFVIITV HCAMRREVQD
AVRCRMGGCK DDSENSPDSC KNGQVQIMTD FEKDVDLACQ TERGHPFIFK DVNTCNPATI
TGTLSRISLD DEDDPKLTAH QEGGVGVNFS SLPGNIPPPN LIVQVPTLGL NELSESPLKK
ELNMDQQRQQ GQQRNNTPIY LCTESGLGWA RPPASSNNSQ DGSAGSGGSG GGSGGGGEGD
YMVLPRRTVS LKPPASSSQG VGLGLGGEDQ PLNIAVEDAP FPPPPSPLTL HPAESEAYPA
DFVPSSVGDM NITMNLNRSY GTIKTMPHGH GHLMAQGGLV HSHGGHIHSH GHSLHLKAGQ
RPSVRQILTS GPTVERTRTL PRNLGSTNAN TSHSAGSLER KRVRYSELDF EKVMHTRKRH
SELYHELNHS SKFHTIDRYN RDPAMSTFKR GKRWSISSAG GEKNSLSDKS TPEDQSSWDS
FKTMTPELSI VPGEQKDRLE LHNKNWDSSS ANTPDSSEGD FQTEDLSRWA PRLR
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