ID A0A3B3I014_ORYLA Unreviewed; 3038 AA.
AC A0A3B3I014;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=BRCA2 DNA repair associated {ECO:0000313|Ensembl:ENSORLP00000037069.1};
GN Name=brca2 {ECO:0000313|Ensembl:ENSORLP00000037069.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000037069.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000037069.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037069.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000037069.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037069.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000045827.1; ENSORLP00000037069.1; ENSORLG00000030193.1.
DR GeneTree; ENSGT00390000003602; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000030193; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 11.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 11.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 12.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2541..2582
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 87..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1968..2003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2053..2093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2904..2956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2904..2949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3038 AA; 331589 MW; D2A3A059DBA0B9DE CRC64;
MFSFFHISTD LLSTPNKSTT SYAKHISESL GAQINPDISW TSSLNTPPAV PSTLILSRAD
NKPCTGNAPT DGNIVFVRKL FPSLSKSSAS KASKNNDPIA FQGPHSPKFD PETFSNQEER
VWQQKLPDAI EDGDVRSAVA DVLDGAEDAL SIFFANSSSA LRKVKPERTK RKQILQAKEN
AYSSKDDLTG SKASSDEEGN GHLEPGGCSL SPLLKMGHAA TSQWSPLSLS EIPLCSVGGN
VVQEQLQGEA NSSQFSGPSK EIQNAEFQSK KRFVDTVGIP EPQSMKINSS VEIPCSEGLC
VGKVESAPNN TDCCNAGKTE GLKQNQPVEV NLVGTVKTNM SQLCREFAQD FSQIPESRDH
FSPSACLSAM KKAKQKAGEG NPHHQCNSIS NSMFPISDVP VNDSGFHSAI VNGTNLTASS
FSENIGLSRT HTELKSEFHT ETVFPPTKAF PETWPSGTKA DIELISAETS KEKEVDPGRA
NKSPTDVTIQ QPSRTGDIHS IAINDPKHDG QTKKTSTSLP AAHSLGFKTA SNKGIHISSA
SLKRAKQIFK ETESETAFYD QPTTSDCDTT KRSTNNKTGN ISTFSLKPTQ TSITETFGSI
TPQLTASQTD DVTELCSLLE QTDSQFELTP FKTLKAKQQD DGNSPQKADK ELDPDFLAGI
DFDDSFSSDL LQCARNENIS PSLKDNCQDE ASVVSDDPQR AVQASKLQSK VSGVAFKTAG
GKVLRVSDKC LSKAKALFAD LDGFTTNRES SSNKSTEIGF NTKQKCAMDP SRCTKNPTYT
VKEDVHAERV GNCFKNHEEL ASENEKPQTP KQHVSGCSVT ENAKLLPCRI KEPHLEMVKV
DSNQLKALKM TAPFHRNSFS ASKPDPSLLC ITSKTIDSNE NCPAAAAAAG FCTAGGKKGF
VSTDKMEYCE YLLKEIHTPE NGKGQLEENK STSKAANPTD QGLQPKICGF QTAGGKELTV
SFAALKKAQE LFSENEGVNE KKRVLILPSR IPSTESSGFC TANGKSVGFS SQALQKAKAF
FSDISVNTVQ PGVSDAGTVK KHKDVPCNGE KMYSAFTASN EADAYASEEH QLKSKHLLKD
FDLVSDKEMQ EADVFLENDV CVENAVFPKD QECQPPLSEM GNEKISNPGQ RATLNFSEPV
SGCPEDLLSF QKVGFQTAGG AKVHVSTTNL IKAKHLFKDL DDLVSDKEMQ EADVLLKSDV
DAENGVFPKD QECQPPLSET GNEETRSDPG QRESLNFSEP VSGCPEDQNV DMLSFQNVGF
QTAGGAKVHV STTNLIKAKH LFKDLDDLVS DKEMQEADVL LKSDVDAKNG VFPKDQECQP
PLSETGNEET RSDPGQRESL NFSEPVSGCP EDQNVDMLSF QNVGFQTAGG AKVHVFSFSG
NKADISQKWT TERNQDKVDD KDKIHFGFQT AGGAKVHVSK TNLIKAKHLF KNLDDLVSDK
ELQEADVLLE NVDVDAENAV LTKDQECQLP LSEGANEMVR SSPDERGSGP SEDTNQRILP
NVDLLSFQNV GFQTANGKAV TFSSESLRKA KSMFNGCEAP ADKTLPTPLQ SKASVLPFRG
GFCSASGTPA SVSSEAVSKA KSLFSDISLS GNKADVSQTW TTEQNRDKVD DKEKIHLGFQ
TAGGAKVHVS KKNLIKAKHL FKDEDDSALK AAQRTDFSLY NSSETSSPLR KTTGLTADLS
KQDQRIMVNP SEGPADGWTE SKTTSVKEKA NVLLHQNAGF QTASGNAVVV SSEALKRAKA
LLSEGEEVAT PPLCKIPVSA SSGFFAASGK AVTFSSKALQ KAKSLFSDIR ADGPDFTDTR
SVKQKQEDAP GLKDKMLCGF TSAGGRVCVA ERSPAKTDNL VAEVADDCRS DSSGFKKLDL
FNVKDVRRSS DVDLSNLAPS EAAVQSENYK PETSHVMVCN SHHESGSNTS RNTRAEESSA
LIFQSLNLTG CTETQHRLLA QEALDCTKAL LEDEDLACLR FSPASQNALK QDYPQTTSGT
EAEEKGPRKR LIGDPDPTGQ PPLKRQLLEE FNQTDDGSKD SALQPVKSCP LGLMKDRGVF
KYSSSLYPNI TKPHYNGKTK TTTVQPLTPD DSRSTRPKMS PFVPPFHKNA RSDASKTTVI
QQATRTPVFV PPLKKQRAVL QGEKDQNTNQ LPSVTESNSI SHVPSTINAQ ECSSALSIVN
THPNNKTNNP NVDVNGGSVC FESHAVPAFS KVFLNTELGR DMQDMRIRKK KRQNIRPLQG
SLFLTKTSGV AKIPLKDAVN GKVPARCPPE QLYRYGVHRQ VSGITSETAE SFRFDLLHFF
KQDVLIDEGG VKLADGGCLI PSKDGTAGKE EFFRALCDTP GVDPKLITEA WGYNHYKWII
WKQASMEKSF PERMGGICLT PEQVLLQLKY RYDVEVDHSR RPALRKITEK DDTAAKTLVL
CVCGIASKGG GASGSESSDP KTQAPTAVVW LTDGWYAIKA QLDQPLTAML NKGLLAVGGK
LITHGAQLVG SQDACPPLEA PESLMLKICA NSTRRARWDT KLGFHRDPRP FLLPIASLFS
NGGPVGCADV VVLRSYPVQW MERKADGGVV FRTTRAEEKE ARRFDEMKHK AMEVLFAKVQ
AEFENEEREK NKSLRRKQNL DVAKLQDGEE LHAAVGDDPT YLEAHLSEQQ LQTLHAYKRS
LMERKQAELQ DRYHRALEED DQEIKCPKRD VTPVWRLSVA DSLGPPSCVY QLSLWRPSSD
VESLLKEGGR YKVYNLATAE GKKRSSHETV QLTGTKKTQF QVLQASQQWM SERFQPRVST
DFESLQNPDF RPLCGEVDLS GYVVSVIDAQ GSSPAFYLAD GKLNLVKIRC FSSLSQTGLE
DVVKPRVLLA LSNLQLRGQS MFPTPVVYAG DLTLFSINPK EGHLQESLSQ LKNAIQHEAN
FHVNAEEKLS HLIKSGRSSF VSPMTVKQQT LPLSSDKKDQ SKVTLQKPIR SPGSVTPVSK
NPQAETSSTK KDPKILKRRR ALDYLSRIPS PPPLSVLDSV SSPCVKKTFN PPRRSGTANE
FRTEKAIKPT DSLVEDQWVN DEELVMIDAQ ALHVGGLM
//
