ID A0A3B3I016_ORYLA Unreviewed; 1019 AA.
AC A0A3B3I016;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000037192.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000037192.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037192.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000037192.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037192.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR AlphaFoldDB; A0A3B3I016; -.
DR Ensembl; ENSORLT00000036898.1; ENSORLP00000037192.1; ENSORLG00000024925.1.
DR GeneTree; ENSGT01060000248608; -.
DR InParanoid; A0A3B3I016; -.
DR Proteomes; UP000001038; Chromosome 15.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 130..309
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 651..818
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 951..1009
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 999..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 115142 MW; B5490B0E5DD356E2 CRC64;
MSFYVVESLK PPVILGFPWL SRHKPHIDWA SGRFLSWSPF CLLNCLASAS VRKVVEVQKS
PEPPDLCKVP SVYHDLGSVF CKVRASSLPP HRPYDCAIDL LPGTQPPRGH IYPLSPPERE
AMDSYLQESL QAGLIRPSSS PAGAGFFFVG KKDGGLRPCI DYRALNTITV RNTYPLPLLH
SAFDLLSGAR IFTKLDLRNA YHLVRVREGD EWKTAFNTPS GHFEYLVMPF GLTNAPAVFQ
RLINDVLKDM LNQFVFVYLD DILIFSPDPE SHVQHVRAVL QRLLENHLYC KAEKCEFHST
QTRFLGYVVS PGRIQMDNSK VKAVLECPVP SGRKQLQRFL GFANFYRHFI RGFSGVAAPL
HKITSAKVRF VWDKEAERAF CELKRRFSTA PILTLPDPSK QFIVEVDASE SWVGAVLSQR
ASDNKIHPCA YFSRKLTPAE RNYDIGNREL LAVKVALEEW RHWLEGAERA FLVWTDHKNL
EYIRSAKRLN PRQARWTLFF DRFNFSLSYR PGSKNIKPDA LSRQFQQEEV EENPTEATPI
IPGHLVLGTT RWSLERRVQA SAPDPASIPS GCPEGRLFVP SDLRTMVLKW GHSSRLACHP
GVTRTGFLIA QRFWWPTMSS DIRAFVSACP VCASVNTPRT LPAGLLHPLP VPSRPWSHVA
MDFITGLPNS RGKTVILTII DRFSKLAHAI PLQKLPSAKE LATLISQHLF RLHGIPLNIV
SDRGPQIIAA FWKEFCNLLG IKVSLSSGFH PQTNGQVERY NQDLETSLRA MCSKNPKTWA
AQLPWVEYSH NSLVNSTGYS PFQAAYGFQP PLFPHQEQLA SSSGPAAFVR RCRRTWSRFR
QELLRNQERL TVVANRRRTP APEYKVGDKV WLSATDVPLK GGSRKLQPRY IGPFSITRII
NPVAVRLELP SSLRIHPVFH VCKLKPAKVS SLQPAPAPPP APRMVDGGPV YTIRELLASR
RVGRGVQYLV DWEGYGPADR QWVPERHIYD PGLIARFHRL HPDQPRRGPS GSRTSGRGL
//
