ID A0A3B3I185_ORYLA Unreviewed; 1005 AA.
AC A0A3B3I185;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=LOC101169865 {ECO:0000313|Ensembl:ENSORLP00000037607.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000037607.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000037607.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037607.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000037607.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037607.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3B3I185; -.
DR Ensembl; ENSORLT00000044497.1; ENSORLP00000037607.1; ENSORLG00000029815.1.
DR GeneTree; ENSGT00940000164983; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000029815; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF342; PROTOCADHERIN GAMMA-B1; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 697..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 144..252
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 253..357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 366..462
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 463..572
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 587..684
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 790..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 110998 MW; EE19EEF0C0ADC65D CRC64;
MLKSVYETCW KLRGYRSDRT MNQRVLLFVC LVSLASVLGQ VSYSIPEEMP KGSLVGNIAQ
DLGLEMKRLI SGKAKIYSRN SGEYVELNRE RGVLLVKERI DREALCAETA LCALHFQIIL
ENPMEHYTVN IQITDINDNA PAFEKTTVEF RISESAIIGA KFELATAEDS DVENNAVQRY
ELKPTNNFDL NLHSNPDGTK NVEMVLQKPL DREKEEQISL MLTAVDGGEP QMSGTMMIVV
TVLDVNDNAP VFTQQTYKVT VTENSPKGTV VAAVTASDAD QGSNSRITYS ITNRVGNFRN
LFEINKENGK VILNEKIDYE KSKSFQITVG ATDDGGLTAS CKLIVDVLDI NDNKPEINIM
SKSNIIPENA KLNTVVTMIH IEDLDSGNNG KVQCLMNENI PFLLKSTINN FYSLQTDSEL
DRETASEYNI TVTCSDEGVP SLSSSVTLTL QISDVNDNAP VFERSSYEAY IVENNTPGVS
IFTVKATDAD WKQNARVSYI LEDSSVNGVP VSSYVSVSAD SGVIHAVRSF DYEQIKDFRF
CVKAQDGGSP PLSSNVTVKI QIQDQNDNPP QVLYPVQTAG SVVAEMVPRS ADVGYLVTKV
VAVDVDSGQN AWLSYKLQKA TDRALFEVGS QNGEIRTVRQ VTEKDLLKQR LTVIVEDNGQ
PSRSATVIVN VAVADSFPEV LSEFTDFPHD KEYNDNLTFY LVLALAVVSF LFITCLVVII
SVKIYRWRQS RILYHSSLPV IPYYPPRYSD TLGTGTLPHT YNYEVCRTTD SRKSDCKFGR
AGSQNVLIMD PSSTGTMQRM QSEKSILDEP DSPLEQKPPN NDWRFTQGQR PGPSGPHMPY
GTHIRWTPKN GTRATGGPEV AMGTGPWPQP PTEAEQLQAL MAAANDEKQQ VPWHYGSLHG
STRLKSQSSN VSEATATLGP GTMGLSTRYS PQFTLQHVPD YRQNVYIPGS TATLTSNPQQ
QQQQATAQQA AQQALPPPQA SAQSEPPKAV QTPASKKKST KKEKK
//
