ID A0A3B3I1L7_ORYLA Unreviewed; 880 AA.
AC A0A3B3I1L7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL3 {ECO:0000313|Ensembl:ENSORLP00000037906.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000037906.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000037906.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037906.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000037906.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000037906.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_011483476.1; XM_011485174.1.
DR AlphaFoldDB; A0A3B3I1L7; -.
DR STRING; 8090.ENSORLP00000037906; -.
DR Ensembl; ENSORLT00000028002.1; ENSORLP00000037906.1; ENSORLG00000007774.2.
DR GeneID; 101160345; -.
DR KEGG; ola:101160345; -.
DR CTD; 567921; -.
DR GeneTree; ENSGT00940000155957; -.
DR InParanoid; A0A3B3I1L7; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000007774; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 51..146
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 376..403
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 808..838
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 99943 MW; 8D3E9E21E0519834 CRC64;
MNPEDSSTAL PQKISSMSSS NSSSSSKHDS RQDSWEMVEG LSGILSNAME PQKQEGYMLK
KRKWPMKGWH KRYFFLDKGT LKYGKSRSDI EKGKLHGCID VGFSVMAIKK KAKCIDLDAE
ENIYHLKVKT EEMFDEWVSN LRHHRLYRQN VSTIPNEKSF CFPHYPSPNS PTLADAALIR
RRMSVRRQST VHPAGAFPLG SNSQAKVVAW LQSSEEMDKC SKDLSVCESY LLELNHMLKN
MEVLHRTYSA PSIQALQNST FNSPKKEKRL QRKWRAKTYS KDVKTTLQVP GNISSGSTRL
HASNPNLSTA ALLNGKADPE PLDSPFDVAK LQEDFYSVAA NFHASMKSIM SSLTSERERL
RQCLDHETFL PTSPQVVNLK NTLAAALAQN SELRERLSKI HSESHIVEPT QKNLSAPVQD
CMDNSHTLVH QASNESRASV ADSISEFFDA QEVLLSASSS ENEISEDDSY ISDISDTISV
DNLSNDLETD RSNSGSGDGM VVCRRRSCLP AFTPNGGSIS MWNILRNNIG KDLSKVAMPV
ALNEPLNMLQ RLCEELEYSE LLDRAANTHD PYERMMFIAT FVVSGYASSY YRTGGKPFNP
VLGETFECNR PDKGFRFVAE QVSHHPPISA CHAESKNFVF WQDVRCKNKF WGKSLEIVPV
GTTHVTLPGF GDHYEWNKVT SCIHNILSGQ RRIEHYGEIS IKNTNSDICQ CKITFIKTSY
WSSRVNEVEG TITDNKGKVI HRIFGKWHEA VFCGDPPSAK CIWRANAMPV NHEQYYGFTK
FAIELNELDP SLTPLLPPTD TRRRVDQRLL EEGNLEAAEE QKQRIEQLQR DRRKVLEDNK
EVHQPKFFSK SKDDTWVSNY TYWELREDPG FVHIDFPTLW
//