ID A0A3B3I3V4_ORYLA Unreviewed; 1961 AA.
AC A0A3B3I3V4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NAC-A/B domain-containing protein {ECO:0000259|PROSITE:PS51151};
GN Name=nacad {ECO:0000313|Ensembl:ENSORLP00000038737.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000038737.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000038737.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000038737.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000038737.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000038737.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NAC-alpha family.
CC {ECO:0000256|ARBA:ARBA00009882}.
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DR Ensembl; ENSORLT00000040606.1; ENSORLP00000038737.1; ENSORLG00000029826.1.
DR GeneTree; ENSGT00940000161501; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000029826; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005854; C:nascent polypeptide-associated complex; IEA:InterPro.
DR CDD; cd22054; NAC_NACA; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.20.70.30; Nascent polypeptide-associated complex domain; 1.
DR InterPro; IPR016641; EGD2/NACA0like.
DR InterPro; IPR044034; NAC-like_UBA.
DR InterPro; IPR038187; NAC_A/B_dom_sf.
DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR PANTHER; PTHR21713:SF4; GH09281P-RELATED; 1.
DR PANTHER; PTHR21713; NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED; 1.
DR Pfam; PF19026; HYPK_UBA; 1.
DR Pfam; PF01849; NAC; 1.
DR SMART; SM01407; NAC; 1.
DR PROSITE; PS51151; NAC_AB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1814..1879
FT /note="NAC-A/B"
FT /evidence="ECO:0000259|PROSITE:PS51151"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1683..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1898..1922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..512
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1810..1824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1922
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1961 AA; 213069 MW; 2D24E81D05564C7B CRC64;
MDTRVVMGEE TLLKTAEVQK RNPPNEPSGQ TSSLLDIQSL SHPQGQQKDA QLENSDDKDQ
PHVSQEAEDQ EKAPVQPAYP SMLSPDLATT DDEVPEETEE GETLSKDEVP SNIFSELACP
VALSFSEPAY GVDPLRIGVP SSLDPDLYYT APSTPIKMPT SSSPSHLKHH SYPGSPAYPL
SPGSPSDSED LCSPLTSPSG SYITAEGGSW TSSYTSSTSH STSPNLLFPE EIQEAPACFV
NSLSEIGDEV GEEKGRVGPN REEEKIRNFC LYHPQNFTNN SQVGILDTVI PEEDDASKAD
EMNNPRRSSH SCWVSENTSP TRTSSSTNSQ EDGGESESSL CPLEDANTNS KPIQAGMTLP
LEACFSEENY GQMDAHPDLL STALSPDADS MNMASSSFSP DSPILFLDAF CPGALDRLGP
DSFILSQAAC ANDTLDDDRM IPASLIPFPL HTSLIFKADS MEITLFPTED DNDVEANNRN
ERKDNVDAYG AGEEEADVED DDDEEDDCDI NEEYTSDSAK ETANDSRDSN GEERDESKVE
VKVVEEEQVD DEQEENEQEV DDDDESGSKA VDDPTDEDTS ESFLHSLSET SINDGLDESF
CFQDDTEDSL DSASYNGEED ERLYSTERHA QSLEPLPTDG PDLAQIQHQA DQSSFQEVLL
QTQPNTDEQD NHLQTAALPD ASSKDINNLS KAVDTPLNPE EQTDAASKSV NERGEEKSLY
MQETTGNHEA QQQMTLSLEG QADSSDNLNN RRKNHEIVKK EPSSDEPKDS PNHDQTSTPI
VILASPDSAT MAISTPPIYE QETTSNHSNL QEESTEESPC VNSGTLTLCS NDSEVEPTKE
PERDSFMLLI KPRHKHSESH RAVGASRAAL SKSFSCKHSE PVRVEPLPFI NSGSETEADH
NKGTASVDVG TAECKNDSCP QLNMVSPTND LNKGVFLLSC PKDQNPSSSN IPISASPEFT
SELADNLALT PEHCPGDPAQ ENLRESSLST DEGVLGAVGS SHSPLAISPK RENSETDTSR
ELHPGLGVWC DAGMGLGFGP GFGSRGKCGV WEADESLSLS LGKRYAFEAD SLLMCHTESQ
STQSTIVPNV SSEACTNDNN LFVDDEDNSI DDKTFLIVDE DLIKQGESNL AHWKSIEEIS
EAGGREDESS RFPEDNISNL NTDNDNNETQ IQNTWNNSDY SSFQYLDMGS CVSLNALSGE
MRHESVNVSK SLSNIPLDEI PPKVPGEEPL EDPTVQTSDT SPRQIFEDIA AIGASNVDAA
VKATNTESHL VAPEATKFSL PQGSFGSFTS KSKSDVCRSR NAHKGNLENA VSLLEAEMVD
LRTVGQRKSD VSSVTGIRVD EPKATDAFRG ENSVSVNSGV KEEEGKGKER NEETETKTGK
SSSAQNGSEH VGFHTLTEAP AMKGRRKKQN KQRGSQAGNQ AGLSPDLVEN PKKTTDQTTA
DMWSKGTTGS SKPKRDFNGN NNVSSADLQQ RTSGIQGYNS LSPDVSRQGH CSSAMNASDH
FNIVEEVNQD EHCKQEALDN RPLKDTQRGV TADVNENIDL RKNTPKMFSS ALISTSSSSS
LQCASTLPEN GLSTPVQESQ PVLSAQQSPL SPYPTSSSLF SPSPTSRKFT CPSSDLQQFT
NVFSSTTAGG VSSSSSSTCL SLSPSKSTNE HKQAVCVPDS SHGTLYQPHS HSHVNAINQS
VKQAPTVSTQ DRCRGAGFSE DMTDSEDDVR RPRQDQTHQP RGRSRNGSSK SLPVSHQEVQ
PYQQEERHSG CPINSSQNLP EETDLKNDSS FVASCNESES EGSIPELEEL EPLRPSEPHS
IPSADDTLNR PKQSRSEKKA RKAMSKLGLK PVHGVTRITI RKSKSILFVI SRPDVFKSPV
SDIYIVFGEA KIEDLSQQAH KAAAEKFKVP MMSSPLATPV PPSLTIKEES EEEEEEVDEG
GLEQRDIELV MAQANVSRVK AVRALKHNNN DIVNAIMELT M
//
