ID A0A3B3I5Q8_ORYLA Unreviewed; 768 AA.
AC A0A3B3I5Q8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Adenosine deaminase RNA specific B2 (inactive) {ECO:0000313|Ensembl:ENSORLP00000039441.1};
GN Name=ADARB2 {ECO:0000313|Ensembl:ENSORLP00000039441.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039441.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039441.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039441.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039441.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039441.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3I5Q8; -.
DR STRING; 8090.ENSORLP00000039441; -.
DR Ensembl; ENSORLT00000045888.1; ENSORLP00000039441.1; ENSORLG00000027340.1.
DR GeneTree; ENSGT00940000157252; -.
DR InParanoid; A0A3B3I5Q8; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000027340; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0006382; P:adenosine to inosine editing; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR CDD; cd19896; DSRM_RED2_rpt1; 1.
DR CDD; cd19899; DSRM_RED2_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044460; ADAR3_DSRM_1.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF17; DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 135..201
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 297..364
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 436..764
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..36
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 85640 MW; ECE3B58F710139D2 CRC64;
MASLLGNGGR AAGAQAGQTA KMKLKRRRRR RSKRREKVSM LSALIAPFKY KIPGTGNMED
EDSLSTSSAE VKENRNIGNL EDCSIGSGER QPLLCSDSAR SGSSGLKRKR PLEEDNNGHL
CQLRLIYKKL SWSEAPKNAL VQLNELRPGL QYRMVSQTGP VHAPVFSIAV EVNGLTFEGT
GPTKKKAKMR AAELALKSFI QFPNAPQAHL AMGNISNPTA DFTSDQADFP DTLFKEFESS
SCSDGLSLCN SGSESELLSS ELLSSELLRH GRLLRHTLDL MVQAQQRLGG IVPEPDAPKG
PVAMLNELRP GLRYACLSER AEGRRLRNFV MAVRVDGRIF EGCGRSKKLA KTQAAQCALQ
ALFNIRLAPE GRTGLKVSRK SCLHLPQDFA DSVFYLVKEK YRLLVGGCSP AHTRHKSLAG
IVMTRDLDLR RAQVVALSTG TKCINGEYLS DQGQVVNDCH AEVTARRALL RFLYSQLELF
LSKRMEDWEE SIFVRHKERS YRLRDDVHFH LYISTSPCGD GRLNSPYEIS TDLHSSRHLM
RKHRCHLRTK IESGEGTVPA RCRGPVQTWD GVLQGEQLIT MSCTDKLTRW NILGLQGALL
SHFVEPVYLH SVTVGSLRHT GHLSRVLSQR QERLGPLPVS YRRNQPLLSG LSSAEYQQPG
KAACVSVNWT VGDVQLEVVN TVTGRRRDSG APSRLCKHAL FTRWSRLYRK LGIHASGSAD
GQLMYYEAKM AARPYQTAKQ QWFRSLQETG LGTWVKKPPE QEHFLLSI
//
