ID A0A3B3I608_ORYLA Unreviewed; 723 AA.
AC A0A3B3I608;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039251.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039251.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039251.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039251.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039251.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3I608; -.
DR Ensembl; ENSORLT00000034061.1; ENSORLP00000039251.1; ENSORLG00000025214.1.
DR GeneTree; ENSGT01090000260066; -.
DR InParanoid; A0A3B3I608; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000025214; Expressed in intestine and 5 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR46670; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46670:SF3; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 403..677
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 723 AA; 81664 MW; 0AC132E8C7EA8E5D CRC64;
MNRKYEKIKR VEAFLHCLEI ILQPAFGVFS SFEYVSFKIE LKQTPPLLCI VMYKPPQHSQ
SFTDDFTEML SVVCTDFDGL VITGDFNVHV DNVNDRNAKE LNAVLETFGL IQHVSCPTHS
RRHTLDLLIT RGVTIYNVSV VDVALSDHFC VFFDLSVAPK PPPGPAVVQR RQINESTRAQ
FVEMINPENV SGANVDEMLN SVTSSILNVL DAIAPMKVQL RKHRQEAPWR NDDLVRAQKQ
QCRRAERKWR KSKLQVHYGI YKAELYAYNQ ILCRTRERYF SEIIGSCSSN SRILFTTVNR
LTNPPTQLPI ELVCTPKCNE FAVFFNDKVQ GIKKAINSTT HITIERPPTH SKLTHFIPVT
DQTVQETITR LSLSTCCLDV LPTRFLKSVL NSVLPSITQI VNMSLQSGIF PEALKTAVIK
PLLKKSGLDP TVLNNYRPIS NLPFLGKVLE KVVYQQLTDF LLLNNSFDVF QSGFRPHHST
ETALIKVTND IRLNTDDGKV SVLILLDLSA AFDTVDHGIL LHRLQDWVGI SGSALSWLKS
YLEDRKYFVE IGSCVSDYMG LNCGVPQGSI LGPLLFNLYM LPLGQLICSN NISYHNYADD
TLIYVSLTTG EYGPVDSLNH CLQQISAWMQ NNFLQLNSDK TEVIVFGPQK QREIVSSYLH
SLSLKPSNQV RNLGVIMDSD LNFNSHIKSV TSAAFYHLKN IAKNQKHNVK ARPGDTYSCI
CLQ
//
