ID A0A3B3I6D5_ORYLA Unreviewed; 1077 AA.
AC A0A3B3I6D5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 3 {ECO:0000313|Ensembl:ENSORLP00000039454.1};
GN Name=SRGAP3 {ECO:0000313|Ensembl:ENSORLP00000039454.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039454.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039454.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039454.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039454.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039454.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011472947.1; XM_011474645.1.
DR AlphaFoldDB; A0A3B3I6D5; -.
DR Ensembl; ENSORLT00000028165.1; ENSORLP00000039454.1; ENSORLG00000000702.3.
DR GeneID; 101168198; -.
DR CTD; 9901; -.
DR GeneTree; ENSGT00950000182824; -.
DR OrthoDB; 2904755at2759; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000000702; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF8; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 17..313
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 485..669
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 717..776
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 691..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 358..385
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 695..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 122087 MW; 80C08BA563509244 CRC64;
MSSKFKKDKE IIAEYETQVK EIRNQLVEQF KCLEQQSESR IQLLQDLQEF FRRKAEVELE
YSRSLEKLAE RFSSKIRSSR EHQQFKKDQH LLSSVNCWYL LLNQTRRESR DHATLSDIYT
NNVIVRLAQI GEDVIRLFKK SKDIGIQMHE ELVKVTNELY TVMKTYHMYH TESISAESKL
KDAEKQEEKQ FSKSGDLNVN LLRHEDRQPR RSTARKIEKM KEKRQAKYSE NKMKCTKARN
DYLLNLAATN AVVAKYYIHD VSDMIDCCDL GYHASLARTF RTYLSAEYNL ETSRHEGLDI
IENAVDNLDS RSDKHKIMDM YNQVFCPPMR FEYLPHMGDE VCQVSAQQPV QTELLMRYHQ
LQSRLATLKI ENEEVRKTLD ATMQTLQDML TVEDFDVSDA FQHSRSTESI KSVASESYMS
KLNIAKRRAN QQETEMFYFS KFKEYLNGSN LIIKLQAKHD LLKQTLGEGE RAECGTTRGR
RNARTRIQDS GQPIPPVVES CVRYINLYGL QQQGIFRVPG SQVEVNDIKN SFERGEDPLI
DDRNEHDINS VAGVLKLYFR GLENPLFPKE RFLDFISTIK LESGAERAHH IQQIITALPR
TVIIVMRYLF AFLNHLSQYS DENMMDPYNL AICFGPTLMP IPDGQDPVTC QAHVNEVIKT
IIIHHEVIFP NLRELDGPVY EKCMAGGEEY CDSPHSEPGT FDEADNGTEP HTSDEEVEQI
EAIAKFDYVG RSPRELSFKK GASLLLYHRA SEDWWEGRHN GVDGLIPHQY IVVQDLDDAF
SDNLSQKADS EASSGPLLEE RSSSKNDLAS PCEQSPDYNF GGVTGRVRLR SDGAAIPRRQ
SGPEAQSPTR VADTPPRAAA CPSSPHKMSI SKARVESPEK RRLGTFGSAG SINYPDRKAY
PEGHPLRPAS GATRHSSLGD HKTLETEALA EDIEKTMTTA LHELRELERQ NTVKQAPDVV
LDTLEPMKNP VGSEPGSPLH TIMIRDPDAA MRRSSSSTSE MMTTFKPALT ARLAGAQLRP
PPMRPMRPPP TQHRSSSSSS SGVGSPAVTP TEKMFPNNNT ASGSNVSSDG GDKPGTM
//
