ID A0A3B3I6Y7_ORYLA Unreviewed; 843 AA.
AC A0A3B3I6Y7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039891.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039891.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039891.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039891.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039891.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3I6Y7; -.
DR Ensembl; ENSORLT00000036999.1; ENSORLP00000039891.1; ENSORLG00000023260.1.
DR GeneTree; ENSGT01070000253760; -.
DR InParanoid; A0A3B3I6Y7; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000023260; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 107..241
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 843 AA; 95707 MW; 7E376CCEC7E1E4DA CRC64;
MWNTHEGAFF SALSADVGLQ ESFGEHQISL KSRSEHVAEG TEEAGRETLL NRVYTELYIT
EKLRPEGHTQ HEVMQLETTT KTNQLHDTAI KNPDIFKVLP DQHRSIRVVL TSGVAGAGKS
FSVQKFTLDW AEGLENQDIS AVVPLSFREM NLIRDEQHSL LTLIQLFHPT LQKIPAEQLS
VCKLLFIFDG LDESRLSLDF NNSPLVSDVT HKSSVNVLLT NLIQGRLLPS ALVWITSRPA
AANQIPPSCV DRLTEVRGFN DAQKEEYFRR RFPDEELSSR IISHIKGSMS LYIMCEVPVF
CWITAVVLEN LLTTEQRGEL PTTLTDMYSH FLMVQTKRKK NKYQQEHQTS PQELTETDRE
VLLKLGRLAF EHLEKGNIMF YQEDLQQCGL DVTEASVYSG VCTEIFRREC GIFQKPVYSF
VHLSVQEFLA AVYMFHCYSN RKVKVIENFL KKKMENPSLD EFLSRVMKKS LQSKTGHLDL
LVRFLHGLFV ESNQRLLGGL LGQREKNPET IQRAINNLKE INSKGVSPDR SINIYHCLME
MKDLSVYQEI QEFLKSENKS EKKLSEIHCS ALAYTLQMSE EVLDELDLNQ YKTSDEGKRR
LIPAMRNCRK LSERCGLSET YCEIVASALK SNLSHLTELD LSNNSLKDSS VKVMCSGLES
PNCGLQTLSS WTSSHITAPE HTFLSDCRLK DCNLSQISCK SLVLALKKNP SNLTELDLSG
NYLQDSGFHP LCGFLESPDC RLQTLRLWSC SLSKISCEAL ISALKKNPSN LTELDLSENQ
NLQDSGVRHL CGFLKSPDCR LQTLRSDSTF QLCSDQYDDK FVFIHSEQKC PDSDLQQHLP
AAA
//
