ID A0A3B3I7G0_ORYLA Unreviewed; 1210 AA.
AC A0A3B3I7G0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSORLP00000039762.1};
GN Name=PPFIA1 {ECO:0000313|Ensembl:ENSORLP00000039762.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039762.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039762.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039762.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039762.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039762.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; A0A3B3I7G0; -.
DR Ensembl; ENSORLT00000034854.1; ENSORLP00000039762.1; ENSORLG00000000029.2.
DR GeneTree; ENSGT01050000244900; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000000029; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 886..952
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 978..1035
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1059..1128
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 270..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 636..663
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 225..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 136208 MW; D19DEC237E0D0D7D CRC64;
MMCEVMPTIS EAEGPGGGNG RRGSGSPLQS DSEGHFESLM VSMLEERDRL LETLRETQEN
LGLTQGKLHE VSHERDSLQR QLNSALPQEF AALTKEVNVC REQLLEKEEE IAELKAERNN
TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH HKALDEKVRE
RLRVALERCS ALEEELAISH KELSYLREQS SQKRGLADGT IEVNHNFENA PSTNGKRSSD
GSLSQEEESG SAFGKAGDLQ EVVDRQAADL GQMKERMAAM VSRISELEED LDTARKDLIK
SEDMSTRLQR DLRESMAQKE DMEERITTLE KRYLAAQREA TSVHDLNDKL ENEVANKESL
FRQAEERNRQ LQEKLELAEQ KLQQTIRKAE TLPEVEAELA QRVAALTKAE ERHGNVEERL
RQLEAQLEEK NQELLRARQR EKMNEEHNRR LSETVDKLLS ESNERLQLHL KERMSALEDK
NTLIRELDHM KKLIEESHHE KEQLLIQIET MRAENEIGRS NSSLHGRSQL GSTPDFRYPV
SASSMMDGNS DSFGSALVLR RPQKGRMVAL RDEPSKVQTL NEQEWERMQQ ANVLANVAQA
FESDMDVSDL EEDREMMFNS VDLLSPAGQA DAQTLALMLQ EQLDAINNEI RMIQEEKEST
AIRAEEIECR VGSGDSIGGR FRSLSSIPPS LCAGSSLGGS PPSSGHSTPR RIPRSPNREL
DRMGVMTLPS DLRKHRRKSS QDDKATIRCE TSPPTTPRSM RLNRETGHAS SHEDIRDIRG
LSSLQDGQGS NPSSSNSSQD SLNKAAKKKS IKSSIGRLFG KKEKGRPSLP GKDVPSQAGT
PEAEGSPKEG LGMGSLGGPA EKNRKLQKKH ELLEEARRQG LPFAQWDGPT VVAWLELWVG
MPAWYVAACR ANVKSGAIMS ALSDTEIQRE IGISNPLHRL KLRLAIQEIM SLTSPSAPPT
SRTTLAYGDM NHEWIGNEWL PSLGLPQYRS YFMESLVDAR MLDHLTKKDL RGQLKMVDSF
HRNSFQCGVM CLRRLNYDKK ELERRREDSQ LELKDVLVWS NERVISWIQS IGLKEYSSNL
YESGVHGALL ALDETFDHNT LALLLQIPTQ HTQARAALEH EYSGLLAVGT DRRMDEDDDK
NFRRAPSWRK KFRPKDVRGG ALGASDTLPA NFRVTNSSAA SPSTPPKRSP VDGSQSIQRL
DTATVRTYSC
//
