ID A0A3B3I7S9_ORYLA Unreviewed; 736 AA.
AC A0A3B3I7S9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN Name=ampd1 {ECO:0000313|Ensembl:ENSORLP00000039845.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000039845.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000039845.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039845.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000039845.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000039845.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
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DR RefSeq; XP_004070279.1; XM_004070231.2.
DR AlphaFoldDB; A0A3B3I7S9; -.
DR Ensembl; ENSORLT00000028641.1; ENSORLP00000039845.1; ENSORLG00000000655.2.
DR GeneID; 101172409; -.
DR KEGG; ola:101172409; -.
DR CTD; 270; -.
DR GeneTree; ENSGT00950000183011; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000000655; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF1; AMP DEAMINASE 1; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
SQ SEQUENCE 736 AA; 84884 MW; B2FFFCDC39AF046B CRC64;
MPKVLVPGQE KTDDNMRAIA EKVFASETKD ENTRDEISMF DVAEDCPIIH HEMAHHLHTD
DNVEKRKRLQ RSHTIAVASG GPKAFAAPAA PVEMDAPTYL EVPDFQRVAI LGDYASGVTM
DDFELSCKGL YRALTIREKY MRLAYERFPR TASQYLREIE GETFKVEDQL QPVFMAPPKD
GEDPFDAKSL PENLGYVARM RDGLIYVYND AAAADKHQHK DLPHPDYDTF IDDMNFLIAL
IAQGPTKTYT HRRLKFLMSK FNVHEMLNEM EEMKELKMNP HRDFYNCRKV DTHIHAAACM
NQKHLLRFIK KSYRVDADRV VHNLKGKEVT MKELFQSLNL HPYDLTVDSL DVHAGRQTFQ
RFDKFNAKYN PVGASELRDL YLKTENHISG EYFATIIKEV ASDLEDAKYQ YAEPRLSIYG
CNPNEWTKLS GWFVKHRVFS PNLKWMIQVP RIYDIFRARN FVPHFGKMLE NIFLPVFQAT
IDPQSNPDLS IFLNHVTGFD SVDDESKHSG HMFSTKSPKP EEWDIAKNPS YTYYIYYMYA
NIAVLNQLRR QRGMNTFLFR PHCGEAGAIT HLLAAFMTAD NISHGLNLKK SPVLQYLYFL
AQIPIAMSPL SNNSLFLEYA KNPLLEFHQK GLVVSLSTDD PMQFHYTREP LMEEYAIAAQ
VFKLSTCDMC EISRNSVLQS GLSHQEKVHF LGSDYLKEGP EGNDIRKTNV AQIRMAYRFE
TLCYELNLIK EGLKGE
//
