ID A0A3B3I892_ORYLA Unreviewed; 651 AA.
AC A0A3B3I892;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=NHL repeat containing 2 {ECO:0000313|Ensembl:ENSORLP00000040268.1};
GN Name=NHLRC2 {ECO:0000313|Ensembl:ENSORLP00000040268.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000040268.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000040268.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000040268.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000040268.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000040268.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3I892; -.
DR Ensembl; ENSORLT00000044663.1; ENSORLP00000040268.1; ENSORLG00000004787.2.
DR GeneTree; ENSGT00390000015483; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000004787; Expressed in heart and 14 other cell types or tissues.
DR CDD; cd14951; NHL-2_like; 1.
DR CDD; cd03012; TlpA_like_DipZ_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01436; NHL; 3.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51125; NHL; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..191
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REPEAT 461..498
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 572..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 69981 MW; 1DCDBCA3DF29B6EC CRC64;
MASKCSLSTL FPIQSQLDCD LENATTQEEK EELVHQFLER VDEREDTKIP DFQTGLEWLN
TDAPLSLNKD LAGKVVLLDF FTYCCINCMH ILPDLHQLEK RHSTQDGLVI IGVHSAKFPN
EKILDNIRSA VLRYNICHPV VNDGEASLWH ELEVSCWPTL VLLGPRGNLL FSLVGEGHSE
KLTLFTDAAL RFYGGKGQLK AHALKIRLYK DSLACSILSF PGKVAIDKST QRLVIADTGH
HRILVVSSAG QLLHVIGGPA SGRKDGSLSE ASFNSPQGVA FKGDAVYVAD TENHLIRKID
LSGGRVSTIA GAGVQGTDRE GGAVGVQQPI SSPWDVTLGT AGGEEDNVLW IAMAGTHQIW
ALFLADGKLP KGGEFKAGVC VRWAGSGSEE NRNNSYPHKA GFAQPSGLAL ATEEPWNCLY
VADSESSTIR SLALKDGAVK LLVGGERDPL NLFAFGDADG KGVEAKLQHP LGVAWSPRQS
LLYVADSYNH KIKVVDPKTK VCSTLAGTGE AGDSLGPELT ESCFNEPGGI CVGGEGKLLY
VADTNNHQIK VLDLLSKTVS VFPVSSEVTD STVSKPLGRT KAPPLPKSAA RKEMPPVEVS
AGQTVTMSLT LSLPEGAKLT EEAPSCWVLS AEGNRQKSSL WNDLFYPLVN S
//
