ID A0A3B3IA35_ORYLA Unreviewed; 1087 AA.
AC A0A3B3IA35;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA damage-binding protein 1 {ECO:0000256|ARBA:ARBA00014577, ECO:0000256|RuleBase:RU368023};
DE AltName: Full=Damage-specific DNA-binding protein 1 {ECO:0000256|ARBA:ARBA00031668, ECO:0000256|RuleBase:RU368023};
GN Name=ddb1 {ECO:0000313|Ensembl:ENSORLP00000040924.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000040924.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000040924.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000040924.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000040924.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000040924.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of complexes involved in DNA repair and protein
CC ubiquitination. May play a role in the regulation of the circadian
CC clock. {ECO:0000256|RuleBase:RU368023}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU368023}.
CC -!- SUBUNIT: Component of the UV-DDB complex.
CC {ECO:0000256|RuleBase:RU368023}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU368023}.
CC -!- DOMAIN: The core of the protein consists of three WD40 beta-propeller
CC domains. {ECO:0000256|RuleBase:RU368023}.
CC -!- SIMILARITY: Belongs to the DDB1 family. {ECO:0000256|ARBA:ARBA00007453,
CC ECO:0000256|RuleBase:RU368023}.
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DR AlphaFoldDB; A0A3B3IA35; -.
DR Ensembl; ENSORLT00000037199.1; ENSORLP00000040924.1; ENSORLG00000001399.2.
DR GeneTree; ENSGT00950000183151; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000001399; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10644:SF3; DNA DAMAGE-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU368023};
KW DNA repair {ECO:0000256|RuleBase:RU368023};
KW Nucleus {ECO:0000256|RuleBase:RU368023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 75..335
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 751..1038
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
SQ SEQUENCE 1087 AA; 120435 MW; FD694F2F02E902E3 CRC64;
MSYNYVVTAQ KPTAVNACIT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGR
ISVMELFRPK GESKDLLFIL TSKYNACILE YKQNGDSIDI ITRAHGNVQD RIGRPSETGI
IGIVDPECRM IGLRLYDGLF KVIPLDRENR ELKAFNIRLE ELQVIDVHFL YGCQAPTVCF
IYQDPQGRHV KTYEVSLREK EFNKGPWKQE NVEAEASMVI PVPEPFGGAI IIGQESITYH
NGDKYLAIAP PTIKQSTIVC HNRVDPNGSR YLLGDMEGRL FMLLLEKEEL MDGTVALKDL
HVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLVTCS GAFKEGSLRI IRNGIGIHEH
ASIDLPGIKG LWPLRSEAGR ESDDMLVLSF VGQTRVLMLS GEEVEETELP GFVDNQQTFY
CGNVAHQQLI QITSGSVRLV LQDSKALVSE WKEPQGRNIS VAACNHTQVV LAVGRALYYL
QILAGELKQI STTEMEHEVA CLDITPLGES SSESPLCAVG LWTDISARML KLPCFTPLHK
EMLGGEIIPR SILMTTFEGS YYLLCALGDG ALFYFGLDLQ TGALSERKKV TLGTQPTVLR
TFRSLSTSNV FACSDRPTVI YSSNHKLVFS NVNLKEVNYM CPLNSEGYPD SLALANNSTL
TIGTIDEIQK LHIRTVPLYE SPRRICYQEV SQCFGVLSSR VEIQDASGAI SAVRPSASTQ
ALSSSVSSSK LFPSSTSPHE TSFGEEVEVH SLLVVDQHTF EVLHAHQFLP SEYGLSLVSC
RLGKDPSVYF IVGTAMVYPE EPEPKQGRII VFHYTDGKLQ TVAEKEVKGA VYSMVEFNGK
LLASINSTVR LYEWTAEKEL RTECNHYNNI MALYLKTKGD FILVGDLMRS VLLLAYKPME
GNFEEIARDF NPNWMSAVEI LDDDNFLGAE NAFNLFVCQK DSAATTDEER QHLQEVGVFH
LGEFVNVFCH GSLVLQNLGE SSTPTQGSVL FGTVNGMIGL VTSLSEGWHS LLLDLQNRLN
KVIKSVGKIE HSLYPSTSSA SVSGTYTGAA TGLTKSHVSM PVKGAEQFWT ILLMSTHFNV
IELFFFW
//
