ID A0A3B3IG48_ORYLA Unreviewed; 1604 AA.
AC A0A3B3IG48;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TIAM Rac1 associated GEF 1 {ECO:0000313|Ensembl:ENSORLP00000043123.1};
GN Name=TIAM1 {ECO:0000313|Ensembl:ENSORLP00000043123.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000043123.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000043123.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043123.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000043123.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043123.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8090.ENSORLP00000043123; -.
DR Ensembl; ENSORLT00000028967.1; ENSORLP00000043123.1; ENSORLG00000003407.2.
DR GeneTree; ENSGT00940000156294; -.
DR InParanoid; A0A3B3IG48; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000003407; Expressed in gastrula and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF4; T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 422..530
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 757..824
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 837..918
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1029..1223
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 24..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..41
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1517
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 181238 MW; 9CA03F3E565BF88B CRC64;
MGNVESQNGY HGFYSTGRGY LSRKHMSRSL RISNKQPRRS RHASSGKIEH RNSETSTRSS
STPSIPQSLA ENGLEPFNEA DILPSFGSPI WVDRVAMSLR PLSFHNDLAN PSVHMNTMHI
TLPGPTAEEA QDEDEYTADV KYLQKTCSKE TVSFKKRSKS ADMWRDDSLE FSLSDASQDH
LTSTEEIIDM ANEGDFTDCE GHLQSIPTDS TDRANSLDEL YSNTGPTRRQ PHSRYAKWQD
TNKSVRESDD DKILSPSEED GSSYGAYTLP CRRSHCLSEG LSTHEAATCA SMQGRRAQTI
QDVTGGEGSE YEDSGIDGVM LGEEHQSRRY KTMSASFSVY SMHGRNMFAG SDSGSSGGGG
ATERVQGVYE NFRQELEMSS CQTESIEEAG SALSDEQSTM TSAYQSDLLL SVVQGMVRKA
GKLAVKNFLV HKKNKKVESA TRRKWRSYWV SLKGCTLFFY ETDGRSGIDN NSIPKHAIWV
ENSIVQAVPE HPKKDFVFCL SNSLGDAFLF QTSSQTELEN WITAIHSACA AAVARQHHRE
DTVRLLRSEI KKLEQKIDMD EKMKKMGEMQ LSAVTDTKKR KTILEQIFLW EQNLEQFHMD
LFRFKCYLAS LQGGELPNPK RLLAFASRPT KVAMGRLGIF SVSSFHALLN RCGAAEQVAA
RTETGVRRRT QATSRSCSKR RSRFSSLWGL DTTSKKKTKA HPSVSQVFAD GEEFEKKPPE
CTYLDHVKEN SKSKEETVNN LPRPNTESDI WLPDHLTPSW VCLPNDHPVL TIVQPGESAL
WVLESICKAH ELDPTKHYLR LKFLIENQVQ FYIPKPEEDI CDLLYKEIEL CSKITKVIQF
DRDESCMIGY GFSISVVEED GVQQLYITDV KAGGLAFAKG LNAGDEILQL NGKDSHSLNF
SDMKAAFSQA SLALTVNTLP SVERRQLCYL PPRRSDAAED LYTDIFSQSQ EEILDDRVGL
LLEGSADSLD DDDESFSDFD ECRKSTEQVA AFCRSLHDMN PLDCESSSPS PDSPFPPTAT
LRQLSDADKL RKVICELVET ERTYVKDLNC LIGRYLTPLQ KETFLTQDEL DVLFGNLPEM
VEFQVEFLKT LEDGTRLVPD LEKLERVDQF KKILFSLGGS FLYYADRFKI YSAFCASHTK
VPKVLVKAKS DANFKAFLDE RNPKQQHSST LESYLIKPIQ RVLKYPLLLR ELYSLTDPDS
EEHYHLDVAM KAMNKVASHI NEMQKIHEEF GSVFDQLITE QSSEKKEVAD LSMGDLLLHS
TVTWINPPVS LGKWKKEPQL NTFVFKTAVV FMCKDASKQK KKMGGSHRLS VSSEEKDPFR
FRHMIPTKAL QVRSLGNTDG ENSAVCEIVH TKSESEGRPE RIFQLCCSSP ESRKDFLKTV
HSILREKHRR QLLKTESLPL SQQYVPFGGK RLCALKGARP AINRAASAPT RTLGRRKLVR
NRFTIDTDIV FDRDHDQHDP TSPEESNSRK LQQKSEADEQ QQSEDGDTDR WVEEQFDLEE
YEDQEDMKET DILSDEDEEF CQAPKAQSEE VDLEAPLKAL SLEGAEPEEA ESEISKSPSL
SDTHHDEKLS DMEEVDITDD MEDQKTKGKD EVWVRRESSG SSPD
//
