ID A0A3B3IIT4_ORYLA Unreviewed; 642 AA.
AC A0A3B3IIT4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Hedgehog interacting protein {ECO:0000313|Ensembl:ENSORLP00000043607.1};
GN Name=hhip {ECO:0000313|Ensembl:ENSORLP00000043607.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000043607.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000043607.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043607.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000043607.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043607.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the HHIP family.
CC {ECO:0000256|ARBA:ARBA00010658}.
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DR AlphaFoldDB; A0A3B3IIT4; -.
DR Ensembl; ENSORLT00000026795.1; ENSORLP00000043607.1; ENSORLG00000007341.2.
DR GeneTree; ENSGT00940000158660; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000007341; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR012938; Glc/Sorbosone_DH.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR19328:SF27; HEDGEHOG-INTERACTING PROTEIN; 1.
DR Pfam; PF03024; Folate_rec; 1.
DR Pfam; PF07995; GSDH; 1.
DR SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..642
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017345759"
FT DOMAIN 625..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS00022,
FT ECO:0000259|PROSITE:PS01186"
SQ SEQUENCE 642 AA; 72076 MW; 750EBBD2C48310DC CRC64;
MKHLQFVLVL VVAVNVWECG DAKFGEKGEI ISPRRRRCYD GSLPKRLKKR ERKVLHDGGS
SSSNSGELCH MLYSRVSCCP TRRAAYQILH RMDARIFSTN NTECAHLLDE IKCARCSPNA
QVLFHSLDID RQPHREPDLP RLCLDFCHKF YYTCRGHIPE LFQADVDEFC QYYGRRGAGL
CFPDFQRRQL LGQDSNYLED EKIDGLNRRH KHNCYCAQEV LSGLKQPVAV VHCGDGSQRL
FVLEREGIVR ILTHNLELIK EPFLDIHKLV QNGLKGGDER GLLSLAFHPN YKKNGKLYVS
YTTNQERWAI GPHDHILRVV EYTVSRKNPN QVDTRTVRVL MEVAELHRKH LGGQLLFSPN
GLLHIILGDG MITLDDMEEM DGLSDFTGSV LRVDVDTDSC SSAYSIPRNN PYFNSTNQPP
EIFAHGLHDP GRCAVDRLPS DNGSLVILCT DASGKNTSVG RILEITKGKD YENEPSVYDL
QSNGWAPPVG GFIYRGCQSR RLYGSYVFGD KNGNLQILQK SSFSTSASGE EWQEKAMCLG
SAGSCGSTIV GHILGFGEDE QGEVYILASS KNMAQSHSGK LFKLVDPKRP LSPKECQRQV
EPPELLMTAC SRYCKNGHCT PTGKCCCSPG WEGPFCRIGK CF
//
