ID A0A3B3IJL2_ORYLA Unreviewed; 876 AA.
AC A0A3B3IJL2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=GEN1 Holliday junction 5' flap endonuclease {ECO:0008006|Google:ProtNLM};
GN Name=gen1 {ECO:0000313|Ensembl:ENSORLP00000043857.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000043857.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000043857.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043857.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000043857.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043857.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR RefSeq; XP_011489949.1; XM_011491647.1.
DR AlphaFoldDB; A0A3B3IJL2; -.
DR STRING; 8090.ENSORLP00000043857; -.
DR Ensembl; ENSORLT00000039492.1; ENSORLP00000043857.1; ENSORLG00000024497.1.
DR GeneID; 101167838; -.
DR KEGG; ola:101167838; -.
DR CTD; 348654; -.
DR GeneTree; ENSGT00940000159266; -.
DR InParanoid; A0A3B3IJL2; -.
DR OrthoDB; 26655at2759; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000024497; Expressed in animal zygote and 9 other cell types or tissues.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0000400; F:four-way junction DNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041012; GEN_chromo.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR Pfam; PF18704; Chromo_2; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1..96
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 124..195
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 530..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 98823 MW; 25430DAFA030D74A CRC64;
MGVHDLWSIV EPVRESVSLY SLSGKTLAVD LSLWVCEAQH VQAMMGRVTK PHLRNLFFRV
SSLSLMGIKL VFVMEGTAPK LKAETMSKRT KARYGQFKNP TKCSTNTSRG RFNSILKECA
EMLDYLGVPW VMAAGEAEAM CAYLDSQGLV DGCITNDGDA FLYGARTVYR NFNMSSKDPQ
IDCYQTSRVQ TELNLSRENL VGLAILLGCD YIPKGIPGVG KEQALRLIQA LKGDSLLQRF
IQWREENPTV SGVVVKKVPH CNICRHPGSA TAHGRQGCRL CNSQQYCQPQ DFDYQCPCDW
HSHEQTHQVV SFEANIKKKT LCSPQFPFTE IINEFLVSKD KPVSHFKRRQ PNMMMMQKFA
YEKMEWPKHY TSEKVLVLLT YTELMNRKYG TGVSSQIKPI RIVKSRVRNA VACFEVIWRA
PEHFVFPEDR PVEEQLEVRT VEEESLFRLA FPEVVESYMR SKALVQESKK KRQKRKEKPL
EVSDNVTELL AKMTLHGSST QPQALLPSSS NYNQTEVLVL DSPVCDKQLH KEKVDHSNPI
RPLPPTASED AASPSVSVVI GALHLSDIDW DASSFTSSPT PQANNTTKPE EKTTGKDERQ
EEESGQEASD SVKQPDLDLC YTDCSLRDRL LMRNSSKSLS LTQTDDVVSK YSNADLNFSE
SNSQGKLRKI ISEEKSGFRD KGQCALKVTK EHAQSSREQQ IVAQVRQKMI ENVKFSRNRE
QKHPLIQTAL TSSQRCDSYP GKRDRNNSKQ QTIKKSVCMS LCSSSEESDV ENYNSKPQGT
TKAAPDEIKS NLISNPPLRL VPKTDKLDRK TPCEEVKPLK SVLAQIKNQD IHGPETDGVF
LQSPDSPVTV LDEEDSLICS DSPLPLAERL RLKFMK
//
