ID A0A3B3IJW1_ORYLA Unreviewed; 1446 AA.
AC A0A3B3IJW1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Calmodulin regulated spectrin-associated protein family, member 2b {ECO:0008006|Google:ProtNLM};
GN Name=camsap2b {ECO:0000313|Ensembl:ENSORLP00000043957.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000043957.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000043957.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043957.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000043957.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043957.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR RefSeq; XP_011485060.1; XM_011486758.1.
DR Ensembl; ENSORLT00000043624.1; ENSORLP00000043957.1; ENSORLG00000015700.2.
DR GeneID; 101175684; -.
DR CTD; 558673; -.
DR GeneTree; ENSGT00950000182975; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000015700; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF5; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 206..341
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1309..1443
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 375..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 757..787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 860..887
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 492..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1076
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 159974 MW; F304AF48D07FF3D3 CRC64;
MGDAADDRGM RRTFIVPAIK SFDHYDFTRA KISCSLTWLV AKAFGSDVVP EELAEPLYKD
QYNQEHLKPP VACLLQSAEL YCRAGSLILR SDAVKPLVGH NAVIQALAQK GLYVTDQYRL
VTERDLMSTP IHMSSHLALI DTLMMAYAVE MVSAERVMSC INRFSSPEPL HSEALFQELP
YDTEDAIVTW INKVIEQLRD VLVEEQRLKE ASLQEANSTT HKSPSKWYWR LVPTRYRREH
AQRSTPSLPL VENLLKDNAD GCALTALLHF YCPEAVRLED ICLKETMSLA DSLYNLQLVQ
EFCRNNLNHC CHFSLEDMLY AHPSIKSNYQ VFMAELFWWF EVVKPSFVQP RVVNPNVCEA
TSSCGEAVPV SSPIKQSYAD RPSGQENLSA EGEMRRSSSM SFVDGCAGTW PKGKHSSSRG
ISFEIPLVGD PELLPCEAPS ACGMSRSASS DSLGFKVHYA AKGGMKRQLS ATPVSVNGQH
IPEEDEDFTP QKPLGRNNTF SIKNQNRYSN GLLPDNSKHH GGHMSPSTPP SIEEALKIIH
DTERPHASFG VGDNSFFLHG VEPSPPSGAQ APEDVPVSAK AHLHDRDPNS ASTDEVDTGI
HVRTEDIQSL DEDSSSLRDY SDIDPDWEAM TRSCPLPVRQ EQSRDAVGEA NPDGQKGTGG
DRGSPCASSA PTLPRSHTLS PASSVGGSGG GLVRMTSFAE QKFRKLEGRS SGGTTPDSSD
LNVPYTHKPV SSQFSTPPLP ITSSVAPSPR DPSHLIASEM IQLRMKLEEK RRAIEAQKKK
VEAAFTRHRQ KMGKTAFLNI VKRKGVTAPP SAGGAAAPSL DSSERSTQRS VEQTERCKPD
GAAPKSPFED VGVAPGEADL AEYTRSIERL NTSLGFLQTE MQRLALQQEK IMAMRDTPQQ
SWVISPPAPS PHRQLRELRS SSVTSRGSGR GSVGSLSPVL SSYGSPRATS QAPAGIKRRP
ASFHARTPRT PRPNDLKVTS FSRMLNTPTS VDSLPRLRRF NPSQTQTSPF AYLGPNKDSA
KSKEEPLLNA GESAKEKEVE LQEERAESKG DVPQPDTADV LQQPVQSNTG SQVQGEAQER
GDLVEVSLSE LKPPEVVAEG ETGELYREDQ KMCCGFFFKD DAKEEKDMAA KKAALLEKRL
RREKETQEKK QQQELDQEQK KEAARLKAEE GQQRKDEDKA RMDFIKNECM RRKQLKLMED
MDEVIKPRSG SLKKKPRPKS IHRDVMESSV PSVRLTGVRP RGFSVSSVSL ASLNLADNDK
DQSDNRKNSR PDSTEGFSSC PSAGSRNGEK DWENDSTTSS TPSNTEYTGP KLYKEPSAKS
NKHIIQNALA HCCLAGKVNE GQKNKILDEM EKSEANNFLV LFRDSGCQFR SIYTYCPETE
EMTRLAGIGP KSITPKMIEA LYKYNSDRKQ FSQIPAKTMS ASVDAITIAN HLWQIKKQGT
PKKHPK
//
