ID A0A3B3IMV3_ORYLA Unreviewed; 997 AA.
AC A0A3B3IMV3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045360.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045360.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045360.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045360.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045360.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR AlphaFoldDB; A0A3B3IMV3; -.
DR STRING; 8090.ENSORLP00000045360; -.
DR Ensembl; ENSORLT00000040524.1; ENSORLP00000045360.1; ENSORLG00000024048.1.
DR GeneTree; ENSGT00740000115773; -.
DR InParanoid; A0A3B3IMV3; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000024048; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR46238; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46238:SF8; RIBONUCLEASE H; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 559..818
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 997 AA; 116612 MW; 0C7253A026DCE8DF CRC64;
MRIIHNTLDI PDRSRPGLTT TATDAVNLQG VGGNLTTVGR RKRGGRRVRG QREKGKGRNI
GLRIGTLNVG TMTGKGRELA DMMERRKVDV LCVQETRWKG SKARSIGGGY KLFYHGVDRK
RNGVGVILKR EFVNSVLEVK RVSDRMMSLK LEIEGVMVNV VSGYAPQVGC ELEVKERFWS
ELDEVIESFP RGERVVIGAD FNGHVGEGNR GDEEVMGRFG VKERNLEGQM VVDFAKRMEM
AVVNTYFQKR EEHRVTYRSG GRSTQVDYIL CRRGHLREVN DCKVVVGESV ARQHRMVVCK
MTLEVRKKKR GKTEKKTKWW KLQNEETCEE FRQKLRQVLG GQDELPDDWE TTAEIIRETG
RKVLGVSSGK RKDGKETWWW NEEVQECVQR KRLAKKKWDV EMTEEGRQEY KEAQRRVKRE
VAKAKQKAYD ELYDRLDTKE GEKDLYRLAR QRDRDGKDVQ QVRVIKDRDG KVLTTQESVQ
KRWKEYFEEL MNVENDRERR EEDVVVVEQE VAEIGKDEVR KALKRMKSGK AVGPDDLPVE
VWKCLGETAV EFLTRLFNRI LESEKMPEEW RRSVLVPIFK NKGDTQNCSN YRGIKLMSHT
MKLWERVVEA RLRKKVEICE QQYGFMPRKS TTDAIFALRM LMEKYRDGQK ELHCVFVDLE
KAYDRVPREE LWYCMRLSGV AEKYVRVVQD MYERSMTVVR CAVGQTEEFK VEVGLHQGSA
LSPFLFAMLM DRLTDEVRQE SPWTMMFADD IVICSESREQ VEEQLERWRF ALERRGMKVS
RSKTEYMCLN ERDQGRSVRL QGTEVKKVQE FKYLGSTVQC DGECGKEVKR RVQAGWSGWR
KVSGVLCDRR VPARLKGKAY KTVVRPALLY GLETVAVRQR QEAEMEVAEM KMLRFSLGVT
RLDRIRNEYI RGTAHVACVR DKVREARLRW FGHVQRRDSG YIGRRMLEME LPGRRARGRP
KRRYMDVLTE DMKLANVRVE DVHDRVRWRT MIRCGDP
//
