ID A0A3B3IN06_ORYLA Unreviewed; 843 AA.
AC A0A3B3IN06;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho GTPase activating protein 17a {ECO:0000313|Ensembl:ENSORLP00000045027.1};
GN Name=arhgap17a {ECO:0000313|Ensembl:ENSORLP00000045027.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045027.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045027.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045027.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045027.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045027.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3IN06; -.
DR Ensembl; ENSORLT00000027410.1; ENSORLP00000045027.1; ENSORLG00000028308.1.
DR GeneTree; ENSGT00940000156201; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000028308; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04386; RhoGAP_nadrin; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF3; RHO GTPASE-ACTIVATING PROTEIN 17; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 14..249
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 255..445
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 461..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 169..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 494..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..548
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..744
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..782
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 91058 MW; B33337187BED2734 CRC64;
MKKQFNRMKQ LANQTVGRAE KTEVLSDDLL QIERRMELVR VVSHNTHKKM ASCLQGHIGA
EAEKRHKKLP LTALSQAMME GGNQLGEDSL IGKMMEVCGD AENRLASELM QHELQIEKDV
LDPLSQLAEV EIPNILKQRK QLAKLVLDYD SAKARWLQAT KSIISGTNTQ ALTAKADLLK
EEVDEAMNKV ELCKDQLAAD MYSFFSKEGD YARYFITLLE AQADYHRKSL TVLESVLPTI
QAQQDSWIEK PAFGTALDEH LKRSAREIAL PMEACVMMLL ETGMKEEGLF RIAAGASKLK
KLKAALDCST SQLEEFYSDP HAVAGALKSY LRELPEPLMT HQLYDEWIQA SSVSDPDKRL
QALWVVCDKL PKNNRNNLRY LVKFLAKLAQ DSEANKMTPS NIAIVLGPNL LWAKTEGSLA
EMAAATSVHV VAIVEPIIQH ADWFFPEDVD FNVSGMFVMP TPASNHNNPS DYDCSAAERK
RPNSMVGPET DAARKDNTAN KHSDHTLRRG SNTLSRKQHT SPAFQPPLPP VEAQPGAEPQ
PPAPAGGSGP DTSPHSLTQS PPPPLPQHTE ELSNPKLRDS APGPTPMPQR NGCGGGSQAA
GQQAAGGSGS GSTGPSPHMM RRGTKKQAPA PPKPTNPPPS QPGNSSNHAF SSGSSQSTSP
TPRPVSSHFP TSPTSPLQPC ATPRRQSNQA PIQAPNHPPP EPPTQSGSPA SLSQPSGDQH
SAEASPPGTP TPPDTPPPPT TGQDVVAPPS QSLYQSGSLP RPRPVPKPRN RPSIPPPPQP
STASSETNGV CGSAYKTMDP TLGGLRRALV PELAVDQQAV MTSSSSFLPH PRDCDLDTES
TVL
//
