ID A0A3B3IN13_ORYLA Unreviewed; 3140 AA.
AC A0A3B3IN13;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045346.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045346.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045346.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045346.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045346.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 8090.ENSORLP00000045346; -.
DR Ensembl; ENSORLT00000037582.1; ENSORLP00000045346.1; ENSORLG00000028590.1.
DR GeneTree; ENSGT00940000167693; -.
DR InParanoid; A0A3B3IN13; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000028590; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0036156; C:inner dynein arm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF359; DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1098..1250
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 575..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1791..1867
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2381..2408
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 582..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3140 AA; 353857 MW; A342169700178A09 CRC64;
MVKLVSSETT DSKICQSLMD GLSTMEAIFC QMVDILPTLC DQFPRLWFLS DSEVIELLSY
QQTPFTLQPF VCKLFQGVCW LAFDSKLSSN TNDGKSCAAS TQGQKEMNVS GVLGTFQEQV
VFCPSLEVDP NTLAWLFSFE KQLKLTIKRL MKKCAVQQNQ IQPFVLDSPC DKAETEIQAH
YSHHKENALP VLGLLSEFPL QCLLVAEEVN WCRIVLQAFQ KTSLGGLRNL KAHNLAKLEN
LGETIRSTFN GSEMTPQVSK HSSMCLRALV HLTMNHAQQL SRLMEVPHDP ELSFEWISLM
KYHFNSEDQN ALDSDDLTCY VDVLDHRFQY GFEYFGPEDW VMVHTPSTDQ AILGILMALK
SYRSGFVSRN SMSGQNHTIV QLGKALGQQI VVKQCYPSTT PGFVQQMLLG ALHTGAWLLL
DSVDLLPKGV MSLLGKLLAD IHQFFSRLQE NRKLRLNEEQ EHIETESHIV LARKCISPCP
RYGCILISEE NASMVSENLL RSVRPIALKH PDYRVIAEVM LTSIGFQEAK SLSHRLVSLL
LLAKDSNCLP EHFLDENSCF LAVVQKVVSA SEVHLRHGKS QRQTPNEPSV LTPEKSESTS
SRNGEKDKKE TAKTTKLHCR QMSLKQALME ETAIVKAILC IFITEQKKAS QFNTIFKEAF
PIAYQFPHFQ QYMHEEERNQ IQNAISEELQ QQHLHCDVET ISNALTLYQT LKFSEAVMLV
GASGSGKTTC YKALSGALQR LQESENKCKN ENTSATNFVF ETPKWSSVET RVFFPNTMTY
EELFGCISEA KSWKDGVFVK VLQDLEHDPT CSDVHFKKRD GPSKVKWLVM DGESVGQPGW
LDYITSLCSV QDRRVCLPSG ETFLAPSNLI LLMEMTDLQD VSPAAVTRCS LIYFMGTNVW
KAVWKSEMEA FALENQLDQK TLKMWNCLAK NLFSKTVALL EQNDLKAVNH SERGSSKRNG
LQEITSFFRI LQALYKDLMK QLQKPKTSLN ADRKDGITAA DTDGLGKKEL LTRNIFLVAY
IWGFAGHLHP SHWPQFDLSV RQLLSTCSYK IVVPDEISVF DNFFNFECEM CQKKTQPTTS
IIPKYGKYRH LLNLMLKANQ PVLLVGDPGS GKSNLCKSVL GLDKPYISIP GSPLLSSRDL
RLILNNICSR KQCKYVQETT AKKPSLLLFV DDLHEAPRDV CGKMSAALET IRQSLSKGEF
LTSDTFLQKS LSPGAVNYLA TCCFCAPADP SSSVVSLRLS RLLSIFVLPT LSEDAILSMH
SPWLKGWLKE IPLKYSPEDL SQCIIMATKH LFVTLCDQFQ STAQRPQFMF SQSDLQKVFL
GMCLWKWDIS KTTPQKHVLT GCSPGSVLHV VHLWMHECMR TFSDRLCSDD DRDLFLSLLV
GTAATHYGSI LVDDYQPGKL DNSPARASTV DPALTCPNVK LAERTGSSSP SESIFPTDIK
SPPALTEIIQ HFKVTVPQLT YCPRPFDAVK FTNLQCSYEE TCSYYEQDVN DVLEELNMLT
DRRGANVFND TSRYIVLRQG VSQLLHILRA LLIPWGHGVL MSSVRGTGRK TTVRLAAYLT
GCQLMEVHSG NEKELDEILK KARDKIRTDM VKVIILVHEE VSSSVREKLL MAMAQRTYPV
HHTEDELKSL VSRVTQSRRD CMDSWISDRC MGQIYRNIHT FLLMPFVQPN CCKKPANYET
QRAQLTKALK LSCCVEVFQM LSNHSLIEIA IQCLKGHPFK IAVGDSAESL SLAMAGIHQS
ACQYASVLLG VQAFSTQTFV EFITRFDCLY NKLLKQWKSK NNRLFSSVVH LNVLNNIIVQ
ARENVVKLQE EVATKQQHQK ELLGALEDQK NLLELAVQKC ETEENQLERL KEQLNQAVQQ
AKSLFLLRLR ILESLDPHDL EEVHHYRDPP EGVVRVINSI CLLFNLPPGW ESAKHLLGQP
NFMEELEFFD CCTVTTEQLQ QLEEIIQSPH FEPESVREVS KACESLCRWV LLVYEYCCKR
HQLLLQQQME VLVREAESQV CLAKQQKKED YQCLEDLQLK IQAVQCELDR HLADLHKAES
HEKDISIYDG KFEKQFREWS SDCEKADLRQ KNLPGDALIL AAVISYSGPF GPDIRTELLN
KWRDLCLTGD ININPKDVRA ALFTREDADL ISPPPGFPIC VTERLQLPIG EAVGLNEWQL
ENTLSARLLV KLLLWGHKES CGQRCPLLAD THQHLQMISH GRLSSDENIT LEKEAGLDLV
VCADDPELLE KLDCAAEKGL KVLVTHAERA NPSPEFLKKL MRPAGCWFQG SQQLAQPQPS
KFHIILSTHL PTTLLRSGIH ASILAEVHVV DLSLSSKEIQ ELMLTRLLPP EDGELLIQHL
RLKNYNQLLR GKMAAEKDAV MDHILQSGPL LQKDSDLLPR MAAFEEEMRK IQLEIERVSE
ELEGHECLLA APRRLMELPV GLYQALQAVS CLSPTYYFSL QGFIKVMQEA LCEIDKPSLL
CISGKAANSA IPEILNTMVL QLLVHYRPCL FQSHAAVFKL LALLALLNHN NFCSEAERLA
FIRGLEDLEQ PVTENRLSDV SAITLPSWIP PHIYSQLLLL EQIPSFSGLI ASLCTSPMQW
KEYLSLPSST VVGTVPCRSH SHLSLLQRVL LWKTIVPNCL EGLAGTLEEC LLCLPDRAEL
TEPPHAGNPE VLARYLVNHE GPVILSLPNP KGQTTIQPLS LISQLSRVVV GKNKVQLTVI
YCGTIPEEDA VLSLLDTAVN EGHWIIFYSC HLVDRWDDKL VAALSQLMSS SEERKCLTHP
CFKLWFVTHE TASCSIPAVV RMRALLLACD SPWDLKEELS CSMHHLLSFC QTQSSSDVSA
ENMELFIRCA IFHSVLLQRQ SCKYLGFGRT CPWNQEDLLA LVDATISIAC LCHDKIKVLQ
HLAISLVHGG HVVESADLDA VECVARSCFG AESLSGNGPH ILWDIISTHG HFDLSGVLKI
MDQYFGSFTN GDPDMLGFSA DAASEITKMN SCNLNTLLQA SQNPPGLLRS CITRNRHAKM
PDYRLTRDRL QALRNYLTQK KELNMDGVSC SPIRDFLQTE WNSLFDWVSA LISQLQGPVL
QKMSSYCLLQ LTDLACLEKK AALLSSYLWQ ESTTDPPGAY RLSAFKNPRG FLVALMREAA
PVNHKCISEM ALHFKVRGER
//
