ID A0A3B3INE8_ORYLA Unreviewed; 4574 AA.
AC A0A3B3INE8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Plectin a {ECO:0000313|Ensembl:ENSORLP00000045471.1};
GN Name=pleca {ECO:0000313|Ensembl:ENSORLP00000045471.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045471.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045471.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045471.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045471.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045471.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR Ensembl; ENSORLT00000031295.1; ENSORLP00000045471.1; ENSORLG00000007995.2.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000007995; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 15.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 32.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..176
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 189..294
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 841..898
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1509..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1693..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2122..2211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2441..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2560..2584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4285..4321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4524..4574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 794..824
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1162..1210
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1282..1309
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1381..1475
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1516..1577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2194..2211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4285..4318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4574 AA; 523235 MW; 2DE227518BF89E90 CRC64;
MAGRTEESVR AGAAWHGQMD RGFTYQRSNY IHEMRCEDVG FHLYSQMCCA DERDRVQKKT
FTKWVNKHLI KHWKAECFIS LGVLRKQEEV QRHITDLYED LRDGHNLISL LEVLSGETLP
REKGRMRFHK LQNVQIALDF LKHRQVKLVN IRNDDIADGN PKLTLGLIWT IILHFQISDI
QVNGQSDDMT AKERLLLWSQ RMVEGYQGLR CDNFTTSWRD GRLFSAIIHK HRPALIDMNQ
VYRQTNQENL EQAFSVAERE LGVTRLLDPE DVDVPHPDEK SIITYVSSLY DAMPRVPDIQ
DGVRANELEL RWQEYYEVVT MLLQWIRHHI LVFEEKKFPT SYEEIEVLWR QFLKFKETEL
PAKEADKNRS KHIFKSFEGA VKAGQVKVPP GYHPLDVEKE WGRLHAAILE RERLLRTEFE
RMERLQRIVG KVQTESGVCE EQLNQVETLL QADVRRMSSG KAPQHTAEVE ADLEKAEGMI
RFLFNDVQLL KDGRHLQAEQ MYRRVYRLHE RLVNLRSEYN LRLKSGVAAS QIPMTQLHTV
QVLQQSSKST RPELDEVTLR YAHDLLGWVE DNQRRVDEGE WGSDLANVES QLGSHRGLHQ
SVEEFRSKIE RAKADESQIS PVSKPAYREY LGKLELQYGK LLTASKARLR YLVELHTFVS
AATKELMWLN EKEEEEVNYD WSERNTNMVS KKENYSGLMR ELELREKKVN GVQATGDKLL
RDGHPARKTI EAFTAALQTQ WSWILQLCCC IETHLKENTA YFQFFTDVKE AEEKMKKMQD
TMRRKYTCDR SVTVTRLEDL LQDAADEKEQ LAEFKTHLEG LKRKANTIVQ LKPRNPTTPI
KGKLPIQAVC DFKQMEITVH RGDECALLNN TQPYKWRVVN NKGSEASVPS ICFLVPPTNK
DAVNSVAGLD GNLQRLHAMW QTMFVDLKSL LSWQYLMRDI HIINTWNVSM FKTLRVEEYR
LALRNLEQHY QEFLRDSQDS QMFGAEDRLQ VESNYKRANQ HFHSMASSAE QGSVPPISGD
QDESVCRTYL TKIKDLRLQL ESCENRTVTH LRQPVEKEAL KACALKTAEQ MKVQSELEGL
KKDLSSIAEK TKEILASPQP SSSAPMLRSE LEITLKKMDH VYCLSSVYLD KLKTIDVVIR
NTKDTEETLK NYETCLRDVR KVPNEEKEVE DQRSQLKSMR AEAEADQAGM DRLQDELQRA
TAINDKMMRI HSERDVELEH YRLQVGSLLE RWQAVFSQID LRQRELDFLS SKMKSYRESY
EWLTCWLAEA RQKQENIQAK PINNSKALKE QLSEEKKLLE EIKKNKDEID NCQMSAKAYI
DSIKDYELLI LTYRALQDPL ASPLKKPKVE CASDNIIQEY VTLRTRYSEL LILTSQYIKF
ITDTQSRLEE DEKASEKLKE EERRKLAEMK AELEKQKQLA EAHTISMAKA EREADELKLK
MKEEANKRQD IAVDAETQKQ NIQQELQHLR SLSEQEIRTK SQQLEEALHS HTKIEEEIHL
IRIQLETTTK QKSTAENELQ KLRDKAAEAE KLRKAAQEEA ERLRKQVAEE AQKKKNAEDE
LKRKSEAEKD AARQKQKALD ELQKFKMQAE EAERRVKQAE DEKLRQIKVV EEVTLKSSAT
DLQTKSMPFA QKATELEETL KKEQGTVLQL QVEADQLRKQ QEEANKAREQ AEKELEMWRQ
KANEALRLRL KAEEEAQKKT QAQEEAERQK LEAEQDAKRR AKVEEMALKQ KENAERELEK
QRTFAEQIAQ QKLSAEEECI RLKVDFEHAK QQRSLLDEEL QRLKNEVRTT ENQRKQLEEE
LAKVRQEMDS VLQMKIQAEK EILSKNEKSK QLLESEALKM KQLAEEATRL RAVAEEAKKQ
RQIAEEEAAK QRAEAEKILK EKLAAINEAT HLKTEAEIAL KAKEAENDRL KRKAEEEAYQ
RKLLEDQAAQ HKHEIEEKIA QLKSSSDSEL ERKKDIVEET LRQKQVVEEE IQIIRINFEK
ASKEKSDLEM DLKKLKSLAD ETQKSKIKAE EEAEKLKQLA AEEEKKRKEA EEKVKRITAA
EEEAARQWKA AQEEVERLKK KAAEAKEHKE KAEKETERQV ILAKEAAQKC SAAEEKAQDV
LSKNQQDILA QDKLKEEFEK AKKLAEAAQK AKEKAEKEAN LLRQKAEEAE KQKKAAEDEV
AKQAKAQKDA EKLRKEAEGE ASKRAAAEAA ALKQKQQADE EMAKHKKDAE HALKQKAQVE
KELGMVKLQL EEADEQKALL DAELQRLKDE VGDAIKKKKQ VEDELSKVKS QMDELLKVKL
KIEEENRCLI QKDKDITQKL LLEEAEKMKT LAQEAARLSV EAEDAARQRQ LAESDLAEQR
AQAEKMLQEK MQAIQEATKL KAEAEELQKL KEDAQEKAKQ LQEDKKLIQQ RLEQETEGFQ
KSLEAERKRQ SELFAEAKKL KLKLKELSDA QAKAEEEVAK FKKQADEAKS QLKEKEKQES
EVVVQNLEMQ RLQSTREADD LRKAITDLEK EKEKLKKQTE DLQKQSEQMV TDQQQQIEQQ
KAILKQSFLT DKELLLKREK AVEDEKNKLE KQLEEEVKKA KALKEEQGHQ QKVMETEKKK
LQDKMDEALR KQKEAQAEME TKQKEMEELE RKRLEQEKLL EEENKKLREK LLNFEVASKQ
GAFKTREMEV QTEKVPEEQL VAMTMVGTTK KFLNGSVEVD GMKKDGESAL AFNGIREKVP
AERLFDIGVL TKKDMDKLKK GKVSISDLEN TEKVRSCLKG QGCVGGVLTP SKEKMSVYQA
MKEKKISPSA AALLLEAQAA VGFIVNPVKN TLLSVDEAVK EEVIGPELHD RMLSAERAAT
GFKDPYTGAK ISLYEAMKKE LIEKEQAMKF LDVQLATGGI VDPINSHRVQ LPMAYKQGQF
DEDLNKKLND PGEELKQFID PSSQEKLTYK QLLEKCTKDA ETGLWILPIP EKAAHVEQTY
TDVETKEVFS KSKVDVPFGK FKGKTVTIWE VINSEYFTED QRRELLRQYK TGKITVEKII
KIVITVVEDK EKSSGNVFSG LRAPVPANEL LDSKVINKDL FNKLSNGKIS VKEVSEMEAV
RKALHGSPSI AGLLNELTNE KIPFYQAMKE EVILPETAVN LLEAQAATGF MIDPVKNERV
PVDEAVKSGL VGPELHECLL SAERAVSGYR DPYTGKKVSL YEAMNKGLVK KDHGIRLLEA
QLSTGGIIDP VKSYRIPHEV ACKRGYFDEE ICKILNKNTD ENKVFNDPNS QEAATYAELI
EKCVTDKDTG LPLFPLSKKA QKPNEDRQIT EAKTKEALNH TTMELEHGPF KGRKVTIWEI
IHSEYITEEQ RIELIRQYRI GQVTIEKLIK IVVTMVVEKE DKTHKEPCFE GLRGPVTATS
LFEAKIIDKT TFDQLQQGNV TPKEVGQTDK VRKYLQGTDR VDGITMEGSD EKLSIYQAMK
KKILQHNTGL ALLEAQAGSG YITDPFTNMK HSVDDAVKAG VVGPELHEKL LAAEKAVTGY
KDPYTGNTIS LFQAMKKELV LREHAIPLLE AQFTTGGIID PVSSHRVPSD VAIQRGNFSK
QMCKSFIEPS GDVKGFTDPN TLQRATYKQL LEKCRRDPNT GLCYLPLSKA EAPAHEEKSY
QFTEEHAQKD LANTQIEIPL QRFAGKNMTV WEIMNSNLLP EDERLRLLEQ YRLGQITKER
MLIIIIEIIE QRESLQSEQS MTCDVIRRRI TIEELYSARI IDLQTYNLLK QEKMTIRELM
DMPSVKQYLF GTGCIAGILS DSPPKISIYQ ALKKGQIKPE VALQLLEAQA ATGFIIDPVK
DELLTVDEAV RKGLVGPELH DKLLSAERAV TGYKDPYSGK VISLFQAMKK DLIPEDFALR
LLEAQLATGG LIDPEYYFRL PTDVAMQRGY INKETLDRIS EPTADVRGYT DPTSDEKQSY
AQLLKRCRVD KDSGLCLLSL AGRRLLFKGL RKQITVEELL RSQIISQKTY NDLTEGNITV
EEVSRDVKTF LEGTSCIAGV FVESSKDRLS IYQAMKKNMI RPGTAFELLE AQAATGYVID
PIKNLKLNVA DAVKMGVVGP EFKEKLLSAE RAVTGYKDPY SGKIISLFQA MKKGFILKDH
GIRLLEAQIA TGGIIDPEES HRLPVEAAYE RGLFDEEINA ILTDPSDDTK GFFDPNTEEN
LTYLQLIDRC WTDPETGLRL LLLKEKKRER KTSSKSSVRK RRVVIVDPES GKEMSVYEAY
QKGLIDQQTY LELSEQECEW EEITTTSSDG AVKSMIIDRR SGRQYDIDDA ITRALIDKSA
LDQYRAGLLS ITEFADMLSG NMSGSRSRSS SFGSSSSYPM SPVPSIKTPA TTWNDPTEET
GPIAGILDTE TLEKVSVTEA IHRNLVDNIT GQRLLESQAC TGGIIDPHTG ERFTIADAMN
KGLVDKIMVD RISLAQKAYI GFEDPRTKTK MSAAQALKKG WLYYEAGQRF LEVQYLTGGL
IEPEVTGRVS IDEAVRKGML DARTAQKLRD VSAYSKYLTC PKTKLKISYK DALERSMTEE
GTGLRLLEAS SQSSKGLYSP YSISGSGSAT GSRSGSRTGS RSGSRRGSFD ATGSGFTSTF
SSSSYGSPSY SRRY
//
