ID A0A3B3INT5_ORYLA Unreviewed; 1288 AA.
AC A0A3B3INT5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Rho GTPase activating protein 23b {ECO:0008006|Google:ProtNLM};
GN Name=LOC101173450 {ECO:0000313|Ensembl:ENSORLP00000045549.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045549.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045549.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045549.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045549.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045549.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000035543.1; ENSORLP00000045549.1; ENSORLG00000030584.1.
DR GeneTree; ENSGT00940000157982; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000030584; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 37..147
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 765..956
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 143925 MW; 9929ACAD40D8887F CRC64;
MKQAKGQRYG KVSSNESRRR PLSSGDVEGS LWQGPRTIYL QKNSQGFGFT LRHFIVYPPE
SSIHCLKEEE NSSTPEKKCQ RSRLEPVDTI FVKSVKENGP AHEAGLCTGD RLVKVNGESV
LGKTYSQVIM LIQNSEDILE LSIMPKDEDV LQLAYSQDAA PRGYNLRSSK GLDLIESPPL
CYHSTKCQPN PDTHTLLDNR QCRLGAMDYC PSAEAVLTSG WSGVPDESSY SPTQRNREQF
SSPMNVLDFH FANHNAAITS ATLPPPRKSS LPTSFRSYTS PPCSQALSDW YYSQAKVTEH
VSSHQHSISQ DHLEELAMNP ALGTTLKTSA GKHRRETLLL HHPAAAASHN SCWPRDCGGA
SDSGSRPCSE SLLAAYAEYE HNYGRSVETL TQASQLVSSH SKIIPQKPEQ KEPKASGGHQ
QQSTALTMMP PNGRQPCQQV AEPQTKQVKE EWRGGYKSQK NPFPNKAGHI FQNTQSFSES
SFSGPHLHWS PSTTENSERV MPARPKSASL LSASDEEAVQ TVECKEVTSS ELVLRLKPTL
LPSHRSPLEE VPPQLTSATP SPGSTPSRRA NGSLAQHAFD SLSSIPFIGS IKSRRSSYLL
AITTERSKSC DEGLNTFREE SQVFSKLPKR VRSFFTDGSL ESLQAQEEAC SKRHSTSELG
TTAFSDVRKE GWLHYKQILT EKGKEICFSR QALINKKLND YRKHSLTGNK LDSSPKTYRM
MSPFLAKTDN TSVNRVSKSE ENKALWGISL MKKAKKTSSP KAFGIRLEDC QPAVNHKFVP
LIVEMCCEVV ETIGLEYTGI YRVPGNNAMV SNLQEHLNKG LNINITEERW QDLNVISSLL
KSFFRKLPEP LFTDDKYGDF IDANRIKNTE DRLKTMKKLI HDLPDYYHHT LKFLVGHLKR
VADHSEKNKM EPRNLALVFG PTLVRTSEDN MTDMVTHMPD RYKIVETLIV HHDWFFSDSD
FDQDEKAPED RQSIQPAPNI DHLLSNIGRP GMPGDTSGST TSDSFKSKIS PSPKKDLNPM
DFLPKSIVSA VPRKRKKCLS TPLSSSSVDE DSEHEPVKAS NYGEEEDREE EEQVKEKHAF
PTSEQRQGGG EPASDTSEEA EEWREDLGKE IEIGSTRRSD VPSPLHVVLH APPPVDPYHL
KSHSLATGRS IPFWVPPSMY PNPYQPSSHQ GAQPSHTGQS VRFRKNIVER ARARSMCLDS
ELGKGERRAR GWRTDKVEVI RVMEGTVGPR GSVLSQGSLQ KIDSLPFSFT SPPWIDPKAH
KSSTVVLRGL AQHQRDKTRA LRRHTVVV
//
