ID A0A3B3IP71_ORYLA Unreviewed; 813 AA.
AC A0A3B3IP71;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045820.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045820.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045820.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045820.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045820.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3IP71; -.
DR Ensembl; ENSORLT00000027345.1; ENSORLP00000045820.1; ENSORLG00000023058.1.
DR GeneTree; ENSGT01090000260066; -.
DR InParanoid; A0A3B3IP71; -.
DR Proteomes; UP000001038; Chromosome 18.
DR Bgee; ENSORLG00000023058; Expressed in pharyngeal gill and 2 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR46670; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46670:SF3; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 389..663
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 813 AA; 91515 MW; C188361D8A007229 CRC64;
MHQNASKTTY FSKISLCARH IAQRKVQGFF PCLTFITVYK PPQHSQGFID DFTEMLSVVC
TDFDGLVITG DFNVHVDNVN DRNAKELNAV LETFGLIQHV SCPTHSRGHT LDLLITRGVI
IYNVSVVDVA LSDNFCVFFD LSVAPKPPPG PAVVQGRQIN ESTRAQFVEM INPENVSGAN
VDEMLNSVTS SILNVLDAIA PMKVKLRKHR QKAPWRNDDL VRAQKQQCRR AERKWRKSKL
QVHYGIYKAE LYAYNQILCR TRERYFSEII GSCSSNSRIL FTTVNRLTNP PTQLPIELVC
TPKCNEFAVF FNDKVQGIKK AINSTTHITI QRPPTHCKLT HFVPVTDQTV QETITRLSSS
TCCLDVLPTR FLKSVLNSVL PSITQIVNMS LQSGIFPEAL KTAVIKPHLK KSGLDPTVLN
NYRPISNLPF LGKVLEKVVY QQLTDFLLLN NSFDVFQSGF RPHHSTETAL IKVTNDIRLN
TDDGKVSVLI LLDLSAAFDI VDHGILLHRL QDWVGISGSA LSWLKSYLED RKYFVEIGSC
VSDYMGLNCG VPQGSILGPL LFNLYMLPLG QLICSNNISY HNYADDTQIY VSLTTGEYGP
VDSLNHCLQQ ISAWMQNNFL QLNSDKTEVI VFGPQKQREI VSSYLHSLSL KPSNQVRNLG
VIMDSDLNFN SHIKSVTSAA FYHLKNIAKI KNIISKRDLE ILIHAFVSSR LDYCNGLLTG
LSKRAVKQLQ YIQNAAARVL TKTRKYDHIS PVLRSLHWLP VPQRIDFKAA LLVYKSLHGH
APKYISDMLV PYEPSRTLRT SGGRPPVDTQ SQN
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