ID A0A3B3IU24_HUMAN Unreviewed; 374 AA.
AC A0A3B3IU24;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=HtrA serine peptidase 1 {ECO:0000313|Ensembl:ENSP00000498033.1};
GN Name=HTRA1 {ECO:0000313|Ensembl:ENSP00000498033.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000498033.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000498033.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000498033.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; BX842242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A3B3IU24; -.
DR SMR; A0A3B3IU24; -.
DR MassIVE; A0A3B3IU24; -.
DR PeptideAtlas; A0A3B3IU24; -.
DR Antibodypedia; 32265; 315 antibodies from 32 providers.
DR Ensembl; ENST00000648167.1; ENSP00000498033.1; ENSG00000166033.13.
DR HGNC; HGNC:9476; HTRA1.
DR VEuPathDB; HostDB:ENSG00000166033; -.
DR GeneTree; ENSGT00940000156955; -.
DR OMA; THGWVLE; -.
DR ChiTaRS; HTRA1; human.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000166033; Expressed in tendon of biceps brachii and 204 other cell types or tissues.
DR ExpressionAtlas; A0A3B3IU24; baseline and differential.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF13; SERINE PROTEASE HTRA1; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Proteomics identification {ECO:0007829|EPD:A0A3B3IU24,
KW ECO:0007829|MaxQB:A0A3B3IU24};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 259..348
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 374 AA; 40868 MW; 86A2C52072F34273 CRC64;
MWTVQGAQNP SSKTLISVSK DFLRPLCRAA CLLHNRCLGQ SRWGELHSQL GGQEDPNSLR
HKYNFIADVV EKIAPAVVHI ELFRKLPFSK REVPVASGSG FIVSEDGLIV TNAHVVTNKH
RVKVELKNGA TYEAKIKDVD EKADIALIKI DHQGKLPVLL LGRSSELRPG EFVVAIGSPF
SLQNTVTTGI VSTTQRGGKE LGLRNSDMDY IQTDAIINYG NSGGPLVNLD GEVIGINTLK
VTAGISFAIP SDKIKKFLTE SHDRQAKGKA ITKKKYIGIR MMSLTSSKAK ELKDRHRDFP
DVISGAYIIE VIPDTPAEAG GLKENDVIIS INGQSVVSAN DVSDVIKRES TLNMVVRRGN
EDIMITVIPE EIDP
//
