ID   A0A3B3Q3H0_9TELE        Unreviewed;      1027 AA.
AC   A0A3B3Q3H0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSPKIP00000000160.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000000160.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000000160.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   AlphaFoldDB; A0A3B3Q3H0; -.
DR   STRING; 1676925.ENSPKIP00000000160; -.
DR   Ensembl; ENSPKIT00000024043.1; ENSPKIP00000000160.1; ENSPKIG00000018925.1.
DR   GeneTree; ENSGT00390000009391; -.
DR   OrthoDB; 2725349at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          69..1018
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          221..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          795..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..724
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1027 AA;  112795 MW;  4639385ECB7B35AB CRC64;
     MTPISDPWSL RTASLRHGHT SRPCGATRQP LKRDIMAPTL LQKLFSKKAG AAAAKDYPGP
     DLCWASSELD LNQIRLIVYQ DCERRGRQVL FDSKAIRKLD AADQKNSDDA QTKTQTRCYK
     AHRSGAYTIN APGAPAACQP CDGEALPSYQ YTRPASDVNM LGEMMFGSVA MSYRGSTLKI
     HYIRSPPQLM VSKVFSTRVG STTGSTSTLQ DSFEYIHQEP AAGKSCPSQS GLASQNSSSI
     GVSQPRGDRP QLGPLRLARS ASFFAAHSTP VDMPSRGHNE DGDSGIARSA SLSSLLVTPL
     PSPSSSLTSS CASSYQRRWL RSQTTSLENG PVPRWGNEEI FSLSDESCSS NPAVIRRKKI
     AVSIIFSLPE KEEENRSFQD FFFSHFPLFE SHMNKLKTAI EKAMILCRRI AESSQRVQVY
     LCRVMDALGE FRTTIWNLYM APRVTEPVWL TMVSQAADKS PLCQRFLQEL TLLTEHTAKS
     HFLAALLTAV LTYHLAWVPT VMPSDHPPIK AFSEKQRSQT VDMLAKSHPY NPLWAQLGDL
     YGAVGSPVRL ARTVVVGRRR ELVQRVLQVL TYFIRCSDLQ ENVMRHAGQC AEAPPGGPTL
     TTTLERGEVE RSEYVVVSVR DDPGKPRDAE APPSLGGLGA APSSEPRHMD GAGALGGLPQ
     QSPDLRGPRS VCLPQQSPLL NRVQFRIGSA DSTDSDLESR QREMDQSYRQ YRESLEESSE
     TRPAGGDLEE PPSDCQAQAG PSEHLVQTPE LEPSRKTPPP NPESSASRLQ GATARLGPGR
     LASYGSVGRK LPVRLTGDIR RNESSDSALG DSDEEEASSE QTGMRRGTEA HGGPREEQEL
     PLPRSETFSR PDVNNFGRSL FGGYCPQYMP DFVLHGTGSD ERLKLCLYSD LEHTVLHPAL
     DEPIAEAVCI VADADKLTVQ VATSQRRVTD SSKIGKDVLV SSLVSNLLHS ILHMAKLNIS
     PDFCIMHLEN RLQEVYFKSK MLSEYLKGQK RVHVKELSLV LGIESSDLPL LAAVASTHSP
     HVAQILL
//