ID   A0A3B3Q562_9TELE        Unreviewed;       457 AA.
AC   A0A3B3Q562;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Paired box protein Pax-8 {ECO:0000256|ARBA:ARBA00039822};
GN   Name=PAX8 {ECO:0000313|Ensembl:ENSPKIP00000001747.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000001747.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000001747.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3B3Q562; -.
DR   STRING; 1676925.ENSPKIP00000001747; -.
DR   Ensembl; ENSPKIT00000025673.1; ENSPKIP00000001747.1; ENSPKIG00000019903.1.
DR   GeneTree; ENSGT00940000161868; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR022130; Pax2_C.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR   PANTHER; PTHR45636:SF6; PAIRED BOX PROTEIN PAX-8; 1.
DR   Pfam; PF00292; PAX; 1.
DR   Pfam; PF12403; Pax2_C; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   4: Predicted;
KW   Paired box {ECO:0000256|ARBA:ARBA00022724};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          8..134
FT                   /note="Paired"
FT                   /evidence="ECO:0000259|PROSITE:PS51057"
FT   REGION          150..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  48502 MW;  FACFC95B0EAB4F66 CRC64;
     MSSAPGRGHG GLNQLGGMFV NGRPLPEVIR QRIVDMAHQG VRPCDISRQL RVSHGCVSKI
     LGRYYETGSI KPGVIGGSKP KVATPKVVDK IAEYKRQNPT MFAWEIRDRL LSEGVCDNDT
     VPSVSSINRI IRTKVQQPFN LPLDSKGLSP GHMLIPSSAV TPPESPQSDS HGSTYSISGL
     LGITQAGPEG KRKHDETDED SCRLSLDPQT TRGSCRKQLR PEHLPPLHLD ALDCGFEHHH
     CPPEALPSGG HGKTEQALYP LSLISGCLDG GKASSPAGRS LAAPHSYSVV ADPLQAPPIC
     LKQEMSPEVS STSDSPSGVD SSAFMELQPI AASVSARSGG GGSSHLSHAF RPFSPHGPVY
     GQLSTQSLIA GREMMDSSLP GYPPHIPASG QPSFTSPTIA SMVAGADYSG QAAYTHTPYA
     SYSDTWRFTN SAILGSPYYY SSASRTAAPS STAYDHL
//