ID A0A3B3Q5H3_9TELE Unreviewed; 510 AA.
AC A0A3B3Q5H3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protein O-glucosyltransferase 3 {ECO:0000313|Ensembl:ENSPKIP00000000656.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000000656.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000000656.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-
CC (beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP;
CC Xref=Rhea:RHEA:58116, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:16010,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:58885, ChEBI:CHEBI:140576;
CC Evidence={ECO:0000256|ARBA:ARBA00000570};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-
CC (beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP;
CC Xref=Rhea:RHEA:62016, Rhea:RHEA-COMP:16010, Rhea:RHEA-COMP:16011,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632,
CC ChEBI:CHEBI:58223, ChEBI:CHEBI:132085;
CC Evidence={ECO:0000256|ARBA:ARBA00000273};
CC -!- SIMILARITY: Belongs to the KDELC family.
CC {ECO:0000256|ARBA:ARBA00006063}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3Q5H3; -.
DR STRING; 1676925.ENSPKIP00000000656; -.
DR Ensembl; ENSPKIT00000024554.1; ENSPKIP00000000656.1; ENSPKIG00000019239.1.
DR GeneTree; ENSGT00940000159028; -.
DR OrthoDB; 1826823at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR006598; CAP10.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR12203; KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED; 1.
DR PANTHER; PTHR12203:SF18; PROTEIN O-GLUCOSYLTRANSFERASE 3; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF05686; Glyco_transf_90; 1.
DR SMART; SM00672; CAP10; 1.
DR SMART; SM00557; IG_FLMN; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..510
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017453063"
FT REPEAT 26..135
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 231..476
FT /note="Glycosyl transferase CAP10"
FT /evidence="ECO:0000259|SMART:SM00672"
FT REGION 476..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 58445 MW; 365F106F088A137A CRC64;
MDQHADRLRL KAFLYLLSLF CSSCEGVELG PDRCTVWGSG LDPNVVLPVR YFYIQAADEA
GQNLTYSPGK DSFQVRITAL APGKHVRIHV PRPLDRGDGS FLMLYRLYES ATSGLKVEVQ
HRDRPVGRSP YILPGPVYHE YCDCPKANGA AWQSAMTCPS YEPQILKDFS SFPSIDLQRL
LQEVPRRFSQ RGGLIHYTVL NNQVYRRSLG RYTDFKMFSD EILLSLARKV QLPDVEFYIN
VGDWPLETRK AGDLPGPVPI LSWCGSTDTR DIVLPTYDIT HSMLETLRGV SNDLLSVQGN
TGPSWANKTD KAFFRGRDSR EERLQLVALS RKYPELLDAG ITAFFFFRER EKDMGKASLV
GFFHFFQFKY QVNVDGTVAA YRFPYLMLGD SLVLKQDSPY YEHFYSHLRP GTHYLPVLRN
LSDLIEKIRW AKENDFEAQV IAKNGQILSR ELLQPNRLYC YYYSVLQIYA QRQHGRPTVH
PDMDPVPQPS DHSADCECQQ ETASQEKDEL
//
