ID A0A3B3Q7D1_9TELE Unreviewed; 749 AA.
AC A0A3B3Q7D1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neural EGFL like 1 {ECO:0000313|Ensembl:ENSPKIP00000001306.1};
GN Name=NELL1 {ECO:0000313|Ensembl:ENSPKIP00000001306.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000001306.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000001306.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3Q7D1; -.
DR Ensembl; ENSPKIT00000025222.1; ENSPKIP00000001306.1; ENSPKIG00000019550.1.
DR GeneTree; ENSGT00810000125439; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF2; PROTEIN KINASE C-BINDING PROTEIN NELL1; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..749
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017476438"
FT DOMAIN 269..330
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 432..473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 515..545
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 547..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..633
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..689
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 517..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 535..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 749 AA; 82598 MW; 40344BB60EA7037C CRC64;
MDIFTAILPV LLVTKPVLGF GVDPELQLDI INELEFANAT SGISQVSGLH NNSKAFLFRD
VDRVIHAPAH ITQKLVQLFR GKNEFTFLAS VQQRSSTSGV IFSIHESEHS YFEVESSGLR
EEIRYRYRFR GKPRSETFPY RLADGQWHKI ALSISASHLQ LHVDCNRIYE RVIDPPQMEL
TSGSSVWVGQ HSHKHGLFKG IIQDVKFIFA PNGYIAQCPN LNRTCPSCSD FLGLVQGIMD
LQELLAKMTV KLNYAESRLT QLEKCHCEKS CQLSGLRHRD TELWAEPDNC RNCACKNGVV
ECRRISCPPP NCSADSLPVH IKGHCCKKCS PKCSFMGKVL SEGQRVLTKV CRECKNGVMV
NVTDSCPKLN CTVSEQILPE NKCCNVCRGY DFCAEGIYCG ENSVCKNYNT KAICECKRGY
TSAIGDFTNC EDIDECSTQM HYCHANTVCV NLPGTYRCDC LPGFIKVDDY SCTEQDECAS
SQQSCDRNAI CTNSIQGHTC TCKPGYVGNG TVCRAFCKEG CRSGGTCVSP NTCLCPPGFT
GRHCEKDIDE CAEGLIQCHN HSRCVNLPGW YHCECRSGFQ DNGSYLLDGG SCVDIDECAT
QTHTCWNDSA CVNLQGSFDC LCTSSPPCTG DCLHQGALKQ NGQVWTLEQD HCSVCSCKAG
EVDCWPLACP TLSCEYTAVS EDECCPRCVT DPCLADNISY DIRKTCVDSA GITRLSGSVW
DVPGSPCTTC ICKNGNACCS VELECLMNN
//
