ID A0A3B3QA27_9TELE Unreviewed; 2676 AA.
AC A0A3B3QA27;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dynein, axonemal, heavy chain 5 {ECO:0000313|Ensembl:ENSPKIP00000003532.1};
GN Name=DNAH5 {ECO:0000313|Ensembl:ENSPKIP00000003532.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000003532.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000003532.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSPKIT00000027493.1; ENSPKIP00000003532.1; ENSPKIG00000020741.1.
DR GeneTree; ENSGT00940000155533; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..2676
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017379973"
FT DOMAIN 32..168
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 311..466
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 636..784
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1265..1299
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1485..1540
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1791..1818
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2676 AA; 304881 MW; 437C184D80431337 CRC64;
MKPSSPSTCI RGTYLMSWCY ITLAQALGMS MGGAPAGPAG TGKTETTKDM GRCLGKYVVV
FNCSDQMDFR GLGRIFKGLA QSGSWGCFDE FNRIDLPVLS VAAQQIAIVL TCKKERRRTF
IFTDGDSVEM NPEFGIFLTM NPGYAGRQEL PENLKINFRS VAMMVPDRQI IIRVKLASCG
FIDNVELARK FFTLYKLCEE QLSKQVHYDF GLRNILSVLR TLGAAKRANP SDTESTIVMR
VLRDMNLSKL IDEDEPLFLS LIEDLFPGIQ LDKAGYPSLE TAIDKQVAEA GLIRHPPWKL
KVIQLFETQR VRHGMMALGP SGTGKTTCIH TLMKAMTDCG EPHREMRMNP KAITAPQMFG
RLDVATNDWT DGIFSTLWRK TLRAKKGEHI WIVLDGPVDA IWIENLNSVL DDNKTLTLAN
GDRIPMAPNC KIVFEPHNID NASPATVSRN GMVFMSSSVL NWSPILEGWL KKRSPQEAEV
LRELYSSSFA ELYRFTIQYL EYKIEMLEAF VIMQSINMLQ GLIPPKVRLY KHMERLYVFS
LMWSVGAPLE LEDRRKMEGW LRNHGSIRLD LPAIAAESDH NMFDYYVNQS GEWVHWDTRV
EEYIYPPDNT PEYGSILVPN VDNIRTDFLI QTITKQGKAV LLIGEQGTAK TVIIKGFMSK
YDPESHAAKS VNFSSATTPL MFQRTVESYV DKRMGATYGP PAGKKMTIFI DDVNMPVINE
WGDQVTNEIV RQLMEQNGFY NLEKPGEFTS IVDIQFLAAM IHPGGGRNDI PQRLKRQFSI
FNCTLPSNAS IDKIFGVIGL GHFCPQRGFA EDVRLCVAAL MPLTRRLWQA TKVKMLPTPA
KFHYIFNLRD LSRIWQGMLN ATAEVVRSRT VSTPISLRHE CKRVIADRFT VSEDVEWFDQ
VLAQLVEEEL GEEDRAFVDF GVDSYFVDFL RDAPEATGEE PEDTDFDMPK VYEPMESFPS
LKDRLNMFLA IYNESIRGAG MDMVFFRDAM LHLSKVSRII RTPRGNALLV GVGGSGKQSL
TRLASFIAGY KTFQITLTRS YNTSNLMEDL KGLYRTAGQL GKGISFIFTD NEIKDESFLE
YMNNVLSSGE VSNLFARDEM DEIISDLIPI MKKESPRRPP TNENLYEYFM SRVRQNLHVV
LCFSPVGEKF RTRALKFPAL ISACTMDWFS RWPKDALIAV SEHFLSSYDI DCSPGVKAEV
VHCMGSFQDG VAEKCADYFR RYRRSTHVTP KSYLSFIQGY KTIYKEKHSE LQTLANRMNT
GLQKLKEASE SVAVLSKELE VKEKELQVAN EKADMVLKEV TVKAQAAEKV KLEVQKVKDK
AQVIVDSISA DKAIAEEKLE AARPALEEAE AALQTIKPSD IATVRTLGRP PHLIMRIMDC
VLLLFQRRLN ATKLDPEKNC PVPSWQESLK LMTAGNFLGS LQQFPKDTIN EEVVELLVPY
FEMSDYNIET AKRVCGNVAG LCSWTKAMAS FFAINKEVLP LKANLAVQEN RLAIANADLQ
KAQAELDEKQ AELDVVQGEY EKAVMEKQAL REDAERCRHK MQTASSLISG LAGEKQRWTE
QSKEFAAHSK RLVGDVLLAT AFLSYSGPFN QEFRNLLLTD WQREMRTRQI PFGNNLNLTD
MLIDAPTVSE WNLQGLPNDD LSIQNGIIVT KATRFPLLLD PQTQGKTWIK NKEAKNELQV
TSLNHKYFRN HLEDSLSLGR PLLIEDVGEE LDPALDHVLE KNFIKTGSTY KVKVGDKEVD
VMRGFRLYIT TKLPNPAYTP EISARASIID FTVTMRGLED QLLGRVILTE KQELEKERTD
LLEDVTANKR RMKELEDNLL FRLTSTQGSL VEDESLITVL SGTKRTAEEV TQKLQVAAET
EVQINAAREE YRPVATRGSI LYFLITEMSM VNVMYQTSLR QFLGLFDLSL ARSSKSPITS
KRIANIIDHM TFEVHKYAAR GLYEQHKFLF TLLLALKIDM QSNRVKHEEF LTLIKGGASL
DLKACPPKPA KWILDMTWLN LVELSKLWQF SDILSQIGRN EKQWKSWFDK DAPEEEIIPN
AYDQVLDCFR RLLLIRSWCP DRTIAQARKY VMDSMGERYA ESVVLDLEKT WEESDHRTPL
ICFLSMGSDP TDSIIALGKK QKIETRYVSM GQGQEVHARK LLQQTMANGG WALLQNCHLG
LGFMDELMDM VTESEMVHES FRLWMTTEVH KQFPITLLQM SIKFTNEPPQ GLKAGLRRTY
GGFQDLLDVS NLIQWRPMLY GVAFLHSTVQ ERRKFGPLGW NIPYEFNQAD LNATVQFVQN
HLDDMDVKKG VSWTTVRYMI GEIQYGGRVT DDYDKRLLNT FAKVWFNENM FGADFVFYKG
YAIPKCSNVD QYLQYIQGLA AYDTPEVFGL HSNADITYQS KLAKDVLDTI LSIQPKDCSS
GGGETREAVV GRLADDMLEK LPPDYVPFEV RERLQKMGPF QPMNIFLRQE IDRMQRVMQL
VRNTLTDLKL AIDGTIIMSE NLRDALDCMY DARIPARWKK ASWASSTLGF WFTELLERNR
QFQAWIFEGR PNCFWMTGFF NPQGFLTAMR QEITRANKGW ALDRMVLCNE VTKWMKDDIS
QPPAEGVYVY GLYLEGAGWD RRNCKLVDSK PKVLFEMMPV IRISSRSLKD SRLYSCPIYK
KPLRTDLNYI AAVDLRTVVP PEHWILRGVA LLCDVK
//
