ID A0A3B3QAL3_9TELE Unreviewed; 1256 AA.
AC A0A3B3QAL3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1-like {ECO:0000313|Ensembl:ENSPKIP00000003732.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSPKIP00000003732.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000003732.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000003732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3QAL3; -.
DR STRING; 1676925.ENSPKIP00000003732; -.
DR Ensembl; ENSPKIT00000027697.1; ENSPKIP00000003732.1; ENSPKIG00000021078.1.
DR GeneTree; ENSGT00940000157599; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..748
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1021..1253
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 710..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 800..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 143322 MW; 56157D6DF56E1873 CRC64;
MQKGMRINDG HITYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENDSSS
RPSGLYLLEG CVCDRAPSPK PPLSGKECLE KQYYFTVSFN HDNQKALELR TEDVKDCDEW
VAAISHASYR NLATEHETLM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNGKIQS APAVAPSDED SEIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLE AEAEYVQQLH ILVNTFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHIERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIVEGCEIL LDTSQTFVRQ GSLIQIPMTE KGKITRGRLG
SLTLRREGEK QCFLFSKHLI ICTRGSGGKL HLTKNGVLSL IDCTLMEDAE GTDDEAKPEK
TGQDTEHLDF KIVVEPKDSQ AFTVILVASS RLEKSAWTSD ISQCIDNIRC NGLMMNAFEE
NSKVTVPQMI KSDTSLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT DLRFLSIDFL
NTFLHSYRVF TTADVVLDKL IAIYKKPISA IPARSLELFF ASSQNNKLLY GEPPKSPRAS
RKFSSPPPLS IGKTSSPNRH RKLSLNIPII TGGKALDLAA LSCSTNGYAS MYSSVSPFSK
TTLDISKLYV SSAMSGKMAD EPEPRADRGE EPPLYKPDTA VREESDDGKV QSDDAETETS
PNKSPTTPKT TRCKNASDFS LFSYNNGLVM SPCRELDATR SALSAASAFA IATAGANEGT
PTKEKYRRMS LASTGFPTDQ RNGDKEFVIR RAATNRVLNV LRHWVSKHSQ DFEDSNELKL
KVIGFLEEVM HDPELLTQER KAAANIIRTL TQEDPGDNQV TIEEMRQQAA EVKAEPFENH
SALEIAEQLT MMDHLVFKVI PYEEFFGQGW MKNDKNEKTP YIMRTTKHFN DMSNLIATEI
LRCDDITTRV AVMEKWVAVA DICRCLHNYN AVLEITSSLN RSAIFRLKKT WLKVSKQTKA
VIDKLQKLVS SEGRFKNLRE ALKNCDPPCV PYLGMYLTDL AFIEEGTPNY TEDNLVNFSK
MRMISHIIRE IRQFQQTAYK IEYQPKTAHY LLDLSLLLDE EELYEASLRI EPKVPS
//
