ID A0A3B3QGT5_9TELE Unreviewed; 1684 AA.
AC A0A3B3QGT5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rho GTPase activating protein 23 {ECO:0000313|Ensembl:ENSPKIP00000004999.1};
GN Name=ARHGAP23 {ECO:0000313|Ensembl:ENSPKIP00000004999.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000004999.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000004999.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPKIT00000028991.1; ENSPKIP00000004999.1; ENSPKIG00000021839.1.
DR GeneTree; ENSGT00940000157982; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 46..155
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 786..908
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1000..1191
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 18..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1592..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1684 AA; 184991 MW; 6FBB2811D413492F CRC64;
MNGVAFCLVG IPPYRETEAK GRRDGLSPSN ENVRPGEGVA WQGPRTLVLR KNAQGFGFTL
RHFIVYPPES TMRTGPKDEE NGNEKAYQCS NLEPMDTIFV KNVRENGPAD QAGLCTGDRL
VKVNGESVLG KTYSQVIALI QNCESVLELS IMPRDEDVLQ LAYSQDAYLS GNEPYTGEAQ
DLPEPPPICY PRGRAQSHMG HNQTDKRGCR LAPARVSSPP DNRSGRASPA GWLDDTALEL
RGPNQGSPVH HTEEVQYGVS SQQAVGQPRG HMSPPSSSGP AHASPLHGYY GNHNIGATAQ
ARVGAQPWPS PQKAALSRSE VRQQALTDWY YSQVPERRGP SMPPRYRSIS QDRLGEVGVG
VPPGRQRMGW PHSTSQDTLL LQPDSGQYGD SSWAEDWGCT SKHRSGRARS ENLLASKYHR
HGRSMEMLDR AAIMVSPRPD RPAWPPQQAP TPAPRTEVYQ QQGPHYGAVP APPASGRGQS
HQQEQPPASQ PRRLPLQSAD DQPVGYRSYS PSFYRKAGRL MQAHSFRDPS YSGPHFNWNP
TPKTSPQETV AAPPAAPEPR DGTHRPTNHE RPWEEEQPHS QVQEVVLRQK PPTGRRGPPG
QRQPHYGLPA EAAEALGFQG EGPNTATPRS VDAPRRTNGG LAPLTLQDDS LASIPFIDEP
TSPSADLRAR HVPASSVVSS VMSSAPAVTT SPTSPTFAFP LTRLFSHDCS NVKSNRRTSY
LQAITTERSK SCEGLNTFGN EGHMFSILPK RVKSFFTDGS LDSLAPTEIR SKRHSTSELG
SITFSDVRKE GWLHYKQILT EKGKKVGGGI RPWKRVFCVL RSHSLFLYKD KREAVLHGAA
LGGATGSGHG DEEQPISIRG CLADIAYSET KRKHVLRLGT QDFCEYLLQA EDRDDMLSWI
KVIREGSKTD SEELGSCRQA LINKKLNEYR KHSPTGNKPD SSPRVPRIIP PFLMAKMDNV
TGAPRSPKPD SKEESSPPKS PWGINIMKKS KKSGPKAFGV RLEDCQPAIN HKFVPLVVEI
CCGLVEQMGL EYTGVYRVPG NNAMVSTLQE QLNKGMDINP TEERWQDLNV ISSLLKSFFR
NLPEPVFTND KYNDFIDANR MENASERLKT MRKLIHDLPD YYFHTLKFLM GHLKTVADHS
EKNKMEPRNL ALVFGPTLVR TSEDNMTDMV THMPDRYKIV ETLIQHFEWF FSEDLDKDEK
TPVDKEDQQP VPNIDHLLSN IGRTAALPEA SDSTNSESAK SKGSWGSKLD LNAKDLLSIV
SAVTRARKRK KPLSSWPISN STDEDSEQEP GKVSHCGGAE GDTAPRAEGE EDEEDEEEEE
EGREATEEEE EPSCQLVEEA GHEGRALEQE EEGEACKAPT WHSPEDARSI VSGYSTLSTL
GRGPASEGRG EEADDERSEL VSETDNESGF ASRSLTQERP EKPPLPPRSF LYTQYKSSTV
PSPAPTPDPT PAEAPSNPVE RSDSRARSTT PSSSSSSSAT HKLNLRPSFN SHKLIQCDTL
ARKKTRAERA KGRSLSSELV QEPANEEDRT DNGEASMAPV SQAAALAAGS RPEGAGQSRT
PPPAHSANLT SSSPAATGWG SLAAQVRTRI LGSADDLRGV GLRKPVSPET RRRRRAWRRH
TVVVGPGAHS TDPIPVQDPP TADVPKPASE PPGHAAPPPA SEPARQSEHT AAVTRQTSRF
HQCL
//
