ID A0A3B3QGZ4_9TELE Unreviewed; 310 AA.
AC A0A3B3QGZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Secreted frizzled-related protein 1 {ECO:0000256|ARBA:ARBA00020517};
GN Name=SFRP1 {ECO:0000313|Ensembl:ENSPKIP00000004855.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000004855.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000004855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR AlphaFoldDB; A0A3B3QGZ4; -.
DR STRING; 1676925.ENSPKIP00000004855; -.
DR Ensembl; ENSPKIT00000028844.1; ENSPKIP00000004855.1; ENSPKIG00000021780.1.
DR GeneTree; ENSGT00940000159875; -.
DR OrthoDB; 4814466at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF87; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..310
FT /note="Secreted frizzled-related protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017388166"
FT DOMAIN 46..163
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 181..302
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 61..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 126..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 310 AA; 35114 MW; 12C7C93850DD7EA3 CRC64;
MECSSLLLRR PAVLIQVLVL TLGITCTQTS EEEFITWKSY NPPTYGKKPQ CIDIPSDLKL
CHNVGYNQML LPNLLEHETL AEVKQQAGSW VPLVHKGCHP GTQVFLCSLF APVCLDHSVM
PCRWLCEAVR DSCTPIMEAF GFPWPEMLSC SQFPKDEEMC IAMSRANATD TSGSAATEPV
CPPCDNQLKM DIILEHVCAS EFAIKTKVKE VKLENSDRKV ILHKKKKVLK LGSLNRKDLK
NLVLYLKNGA DCPCQQLDHL TNNYLIMGRK VDKKYLLTSI QKWEKSSKEL KKAMKRLNTH
KCPVFETVFK
//
