ID A0A3B3QHF4_9TELE Unreviewed; 671 AA.
AC A0A3B3QHF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Basic helix-loop-helix ARNT-like protein 1 {ECO:0000256|ARBA:ARBA00041169};
DE AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1 {ECO:0000256|ARBA:ARBA00042144};
DE AltName: Full=Brain and muscle ARNT-like 1 {ECO:0000256|ARBA:ARBA00041751};
GN Name=BMAL1 {ECO:0000313|Ensembl:ENSPKIP00000006197.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000006197.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000006197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
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DR AlphaFoldDB; A0A3B3QHF4; -.
DR STRING; 1676925.ENSPKIP00000006197; -.
DR Ensembl; ENSPKIT00000030218.1; ENSPKIP00000006197.1; ENSPKIG00000022574.1.
DR GeneTree; ENSGT00940000157523; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0009648; P:photoperiodism; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:1901342; P:regulation of vasculature development; IEA:Ensembl.
DR CDD; cd11438; bHLH-PAS_ARNTL_PASD3; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23042:SF52; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 121..174
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 192..257
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 396..445
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 558..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 73745 MW; 966DB9DDA2A82D86 CRC64;
MKPATPIHLL HNQRASAPPV IHIQNEYSTY RTPATFVSTL TLHLVFADEL MADQRMDISS
TMNEFMSSGP TDLISSSIGT TGMDYTRKRK GSCTDYQDGL DVDKDKQLGR DCGDQQGRIK
NAREAHSQIE KRRRDKMNSF IDELASLVPT CNAMSRKLDK LTVLRMAVQH MKTLRGAANS
YTEANYKPAF LSDDELKHLI LRAADGFLFV VGCDRGKILF VSESVYKILN YSQNDLIGQS
LFDYLHPKDI AKVKEQLSSS DTAPRERLID AKTGLPVKTD ITPGPSRLCS GARRSFFCRM
KCNRPSVKME DKEFPSTCSK KKADRKSFCT IHSTGYLKSW PPTKMGLDED GEPDNEGCNL
SCLVAIGRLH PHIVPPASSG DIRVKPTEYV SRHAIDGKFV FVDQRATAIL AYLPQELLGT
SFYEYFHQDD IGHLAECHRQ VLQTREKIHT NCYKFKIKDG SFVTLRSRWF SFMNPWTKEV
EYIVSTNTVV SGSTLDNADP SYPQLASSPH SMDSVLTAGD GPGKRALQTV PGIPGGTRAG
AGKIGRMIAE EVMEIQRIRG SSPSSCSSSP LNITSTPPPD TCSPGGKKIQ NGGTPDIPST
GMALGPDSIG YPYSNNSIMS DNSHLGIDIM DEQGSSSPSN DEAAMAVIMS LLEADAGLGG
PVDFTDLPWP L
//
