ID A0A3B3QIY7_9TELE Unreviewed; 446 AA.
AC A0A3B3QIY7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Melanocyte inducing transcription factor a {ECO:0000313|Ensembl:ENSPKIP00000005386.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000005386.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000005386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3B3QIY7; -.
DR Ensembl; ENSPKIT00000029386.1; ENSPKIP00000005386.1; ENSPKIG00000021897.1.
DR GeneTree; ENSGT00940000156326; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776:SF4; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 246..299
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 292..333
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 27..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 49821 MW; 5683762EBFE0FC02 CRC64;
MQSESGIVPD FEVGEDFQEE PKTYYELKSQ PLNSNPSQQH GSHTTSAVTS RVSLRQQLMR
EQLREQERRE QQRASRYLQR QPRSIPSAQT PAIDVSAAPG LPAGAQVPME VLKVTKLPVI
PAFRSCQVPS LVTFAGSQVM SLRCFWRFSC VNECMAPMDD VIDDIISLES TYNEDLLGLM
DPALQMTNTL PLSANLLDVY SGQALPPHSL PVSNSCPANL PNIKREFSVL KSNRCAEVRA
LAKERQKKDN HNLIERRRRF NINDRIKELG TLIPKSNDPD MRWNKGTILK ASVDYIRKLQ
REQQRAKDLE NRQKRLEHAN RHLMLRIQEL EMQARAHGLA LVSPTALCPS ELAGRVIKQE
PVLGDCLRDP YPHPHHASDM SRPTTLDLTD GTITYSDGHG EPGESAPYTR PTKGASKLDD
ILMDGSLSPV RAGDPLLSSS SPGHAC
//
