ID A0A3B3QJV1_9TELE Unreviewed; 667 AA.
AC A0A3B3QJV1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 {ECO:0000313|Ensembl:ENSPKIP00000006393.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000006393.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000006393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 1676925.ENSPKIP00000006354; -.
DR Ensembl; ENSPKIT00000030377.1; ENSPKIP00000006354.1; ENSPKIG00000022606.1.
DR Ensembl; ENSPKIT00000030418.1; ENSPKIP00000006393.1; ENSPKIG00000022606.1.
DR GeneTree; ENSGT00940000158319; -.
DR OrthoDB; 5386756at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd13247; BAR-PH_APPL; 1.
DR CDD; cd13158; PTB_APPL; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047181; DP13A/B.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047236; PH_DP13A/B.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR047237; PTB_APPL.
DR PANTHER; PTHR46415; ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2; 1.
DR PANTHER; PTHR46415:SF1; DCC-INTERACTING PROTEIN 13-BETA; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 275..373
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 493..563
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 399..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74495 MW; D5AF9C4C1C983CE0 CRC64;
MPAVHKLLLE EALQDSPQTR SLLSVFEEDA GTLTDYTNQL LQSMQRVYGA QNEMGLATEQ
LSKQLLEYEK QNFALGKGDE EVISVLQHFA KVVEELNSLH AELATQMAEK MVFPLIQFRE
KDLTEISTLK EIFGIATDEH EVSMVKYSRL PKKRENEKVK AEVVAEVAYS RRKQHQASLQ
YYCALNALQF RKRVAMLDPL LGYTQAQMNF FRKGMDVVSK KMDSFLMSVS NMTQSIQAQL
DSEAESMRMS QRDLLSVDDT VYMPDRDREP VNRTLIQKAG YLNIRNKTGL VTTAWDRLYF
FTQGGNLMCQ PRGAVAGGMV LDLDNSSVMA VECEDRRYCF QITSPTGKTS LTLQAESKKE
YEEWICSLNN ISRQIYLTDN PEAVAIRLNQ TAIQAVTPIT SFEKKHEGSP NRERAKAGST
QPSSEAQQRE PKAPEPEELI APGTPIQFDI MLPASEFLDQ NRAGGRRTNP FGETEEDSVT
DGESADSLLQ QVFAVRFLGS MAVRSGHSPE VIYEAMRQVL AARAIHNIFR TAESHLMVTS
GSLRLIDPQT QVTKISFQLQ DVTQFAAHQE NSRLVGFVVE SQDWAEGGEE GEASYSAFVF
ESNTEGEKIC YTISLGKEII EAKKDPEALA RLLKSMPLTS DGKFLLLEGE VGGAENGAGP
DGLESEA
//
