ID A0A3B3QMR7_9TELE Unreviewed; 812 AA.
AC A0A3B3QMR7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protein kinase C-binding protein NELL2-like {ECO:0000313|Ensembl:ENSPKIP00000006711.1};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSPKIP00000006711.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000006711.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000006711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3QMR7; -.
DR Ensembl; ENSPKIT00000030741.1; ENSPKIP00000006711.1; ENSPKIG00000022842.1.
DR GeneTree; ENSGT00810000125439; -.
DR OrthoDB; 5487at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..812
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017337473"
FT DOMAIN 47..227
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 271..330
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 396..438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 439..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 522..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..600
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 601..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 637..692
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 697..755
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 524..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 812 AA; 89927 MW; 99A927F4C8E51096 CRC64;
MGLLQLSFVL CIFCIISVLG FGVDPALRIS LFNELRLGDT FAGVSQVQGF HNESRAFIFQ
DTARELKAPE GVADEILKKL RNRKEFTILA TVKQEPLNSG VILSVHHAEQ RFLELESSGH
RNEIRLRYRT ESQQPHTDIF PYTLADGRWH KVSVALSASH VLLHVDCNRI YEKVVEPPSM
DLPEDTSIWL GQRNSAHGFF KGVMQDVELL VMPQGYISQC PDLNRTCPTC NDFHGLVQKI
MELQDILAKT SSKLSKAEEK MNGLDRCYCE RTCNVKGLLY REDESWTDGC KNCTCSNGTA
LCQPISCSPP LCPPDSAPAY VTGRCCQECQ PMCTFRKRVY MVGERQALRE SSGKCSLFEC
RDRTMRRVAP PTCPELNCAE TDQLALADRC CSICRGHDFC AEGHNCMENS DCVSLEAGPS
CRCRDGFRAL RDDEAYCEDI DECAEGRHYC RENTACVNTP GSFMCVCSTG YIRIDDYSCT
EHNECDSGQH ACDENALCFN TVGGHSCSCK PGYTGNGTLC KALCEGLCQN GGTCVSPDTC
ICQAGFTGKR CDTDIDECSS GFVECDSRAV CVNLPGWYHC ECRDGYHDNG MFSANGESCE
DIDECGTGRN SCTNDTVCFN LEGGYDCRCP HGKNCTGDCI HDNRVKHNGQ IWVLESDRCS
VCSCQTGLVM CRRMVCDCEN PTVDLFCCPE CDPRLSSQCL HQNGLLAYST GASWVESCQQ
CQCLQGEVDC WPLSCPPVDC DFTVVPEGEC CPRCVADPCQ ADTIRNDITR TCTDEHGLVR
FSGSSWIKRG TECTLCQCKN GHVCCSVDPM CL
//
