ID A0A3B3QPY3_9TELE Unreviewed; 958 AA.
AC A0A3B3QPY3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Sorting nexin-25-like {ECO:0000313|Ensembl:ENSPKIP00000007904.1};
GN Name=SNX25 {ECO:0000313|Ensembl:ENSPKIP00000007904.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000007904.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000007904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3B3QPY3; -.
DR STRING; 1676925.ENSPKIP00000007904; -.
DR Ensembl; ENSPKIT00000031973.1; ENSPKIP00000007904.1; ENSPKIG00000023610.1.
DR GeneTree; ENSGT00950000182856; -.
DR OrthoDB; 5392990at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06878; PX_SNX25; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037899; SNX25_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..288
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 414..528
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 630..750
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 958 AA; 109506 MW; 4667C37EDDDD446B CRC64;
MRPGGCISRR SSSASGAAPL GSPPRFFLFL TAFTLAAAVL FELGDGGLTV TLLFLKLFVY
ASFLAACLSL GTLGLLAKRD PFKITSFDTS RKTPTYLLDL LNKKMGHYSA PQSEPSQARR
VVVSLNVDKA LQEVFDYSYR DYVLSWYGSR SRDQGQLYLL LQQDFWTVVR QLRGRLAGVD
VVRLLCGDVV RALHSHFCDL RAAGTGQEEP PRPFPLHPCL RSPNDELRFM RSCVHLLLLC
LGPAHHTCSL RAALADILTT KVLCPLVEQL SDPDYINRTL LTQLEQREQL SERHRKAYTY
APSYEDFIKL IGSSSDIQFL KQLRYQIVVE IVQATTISSL PQLKKQRDSR GKETAAMKAD
LLRARNVKRY INQLTVAKRC CEARIRLLGG PDYELHEDGL TDELDGMRGQ KILQFEEIMS
SPMYRQQFHI YMERMDKRAL ISFWEQVEML KTVSKSEVPQ QVGDIYQKYF VESKEIPVEK
ALYKELQQTL VGNRGTGVIH RIQGDVYESL RERYYPSFLV SDLCERLLQP QEQHDSTQSS
FEDNDEMVCD TGEELLDGLS EQVSYATSKL QQLHSKLEYK MQALGSIQNS PKPDKKIVCQ
LMEEIAAMEK VQSELQQHVS RTDWWCENLG RWRAIISSGE LVEENGDQVP CFSLTVSLME
ADEADGNHWV VSRKLNDFQI LHRKLTECFP SLKKVQLPSL SKLPFKSIDL KFLEKSKGQL
NAFLEKMLAD ERLCQSELLY AFLSPSPEHL KVIDIQNKTT FSLASFLERL PGDLFSHQET
NTWQDETDDD NDFGCGDEVA EPCFMLIGEI FELRGMFKWV RKTLIALVQV TFGRTINKQI
RDTASWMFSE QMLTCYINLF RDAFWPDGKL AEPEASRSDQ ERQETKERAR QKLLDNIPEA
LQNLVGQQNA RHGIIKIFNA LQEANANKHL LYVSGGNFLT EPYLHVSCYK LLDSHLES
//
