ID A0A3B3QVG5_9TELE Unreviewed; 1054 AA.
AC A0A3B3QVG5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SLIT-ROBO Rho GTPase-activating protein 3-like {ECO:0000313|Ensembl:ENSPKIP00000009620.1};
GN Name=SRGAP3 {ECO:0000313|Ensembl:ENSPKIP00000009620.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000009620.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000009620.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3QVG5; -.
DR STRING; 1676925.ENSPKIP00000009620; -.
DR Ensembl; ENSPKIT00000033732.1; ENSPKIP00000009620.1; ENSPKIG00000024659.1.
DR GeneTree; ENSGT00950000182824; -.
DR OrthoDB; 2904755at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF8; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..305
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 473..661
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 709..768
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 171..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 350..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1054 AA; 119241 MW; 76443E2B0327DA41 CRC64;
MSTQKFKKDK EIIGDYETQV KEIRSQLTEQ LKCMEQQTES RLQLLQDLQE FFRRKAEIQL
EYSRSLEKLA ERFSSKIRSS RDHRKDQHLL SPVNCWFLVL NQTRRESRDH ATLSDIYSNN
VTVRLSQVSE DVIRLFKKSK EIGLQMQEEL LKVTNELYTV MKTYHMYHTE SSSAENKLKE
AEKQEEKQFS KLGDSNEDRP PRRSTVRKIE KMKEKRQAKY FENKLKCTKA RNDYLLNLAA
TNAVVGKYYI HDVSDMIDCC DLGYHSNLAR TFRTYLSAEY SLESSRHEGL DIMENAVDSL
DARSDKHKIM DMYNQVFCPP MRFEYQPHMG DEVCLVTAQP PVQTELLMRY HQLQSRLSTL
KIENEEMRKT LDATMQTLQD MFTVEDFDMS DAFQHSRSSE SLKLASSETY ISKVNIAKKR
ASQQETEVFY FTKFKEFLNS TNLITKLQAK HDLLKQTLGE GEKPEFGTTR GRRNARARNQ
DSGQPIPLVV ESCIRCINLY GLQHQGIFRV PGSHAEVNDI KNSFERGEDP LADDQSGHDI
NSVAGVLKLY FRGLEHALFP KECFLNLMAT TKIESGGERA HHIQQIILTL PRSTIVIMRY
LFAFLSHLSQ YSDENMMDPY NLAICFGPTL MPIPDGQDPV ACQAHVNEVI KTIIVYHEVI
FPSPQELDGP IYEKCMSGGE QYCDSPHSEP GAIDEVDNGT GPHTSDDDLE QIEAIARFDY
VGRTARELSF KKGASLLLYH RASADWWEGR HNGVDGLIPH QYIVVQDMDD AFSDSLSQKA
DSEVSSRASL DSKASSRNDV HSPCEPSADY GFLGVLGRAR LQSDGAAISR RRNGVDTHSP
PGGLEVPPRA AAYPCSPLKM PTSLRCAESP EQRHLATYAN AAGINHPERR AYPEARPLKP
TPGSTRHSKL ADLKSLEAEA LAEDIEKTMS TALYELRELE RQNTAKQAPD VVLDTLEPLK
SSTELTRPQH TITIRDPDAG VHCSSNPSPE MMSTFKPVPS PRLPGAQLRA SSVRAPQMAQ
QCPSSPSPSG RGCPTVPLPR KIFPRDSPPD SGPV
//
