ID   A0A3B3QY12_9TELE        Unreviewed;       945 AA.
AC   A0A3B3QY12;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Chloride voltage-gated channel 1 {ECO:0000313|Ensembl:ENSPKIP00000010535.1};
GN   Name=CLCN1 {ECO:0000313|Ensembl:ENSPKIP00000010535.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000010535.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000010535.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B3QY12; -.
DR   Ensembl; ENSPKIT00000034668.1; ENSPKIP00000010535.1; ENSPKIG00000025201.1.
DR   GeneTree; ENSGT00940000157383; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd03683; ClC_1_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720:SF4; CHLORIDE CHANNEL PROTEIN 1; 1.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        109..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        339..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        449..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          40..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          687..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        704..721
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..924
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..945
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  103709 MW;  DE01F5EE9F19462C CRC64;
     MAADAPQRKA LRYQQTLLYG EYKEQLGSGA QREATTRLLT EKQWGGHVGD TPMAPLTPSH
     PQPVAMETGA PSSGLSNTPP AKKPQPYSVC RECVARIQKY LITKLGEDWI FLVLLGFTMA
     LVSWSMDYAS ARSLQVYKWM YRELRENVLL QFLAWVTYPM VLIIFSSLFC HLVAPQSVGS
     GIPEIKTILR GVILKEYLTL KAFVAKVIGL TASLGSGMPL GKEGPFVHIA SICAAVLSRF
     MSLFSGVYEN PYAYTDILTV GCAVGVGCCF GTPLGGVLFS IEVTSTSFAV RNYWRGYFAA
     TFSAFIFRVL AVWNKDAVTI TALFRTNFRM EFPFDLQELP AFAIIGISCG FLGAFFVFLN
     RQVVLVMRKQ NALTRFLTKH RLLYPAVVTL VIASLTFPPG FGQFMAGELM PREAINSLFD
     NYTWTKIWGS PLPPGLGRST AWLHPQVNVF FIIILFIVMK FWMSAVATTM PIPSGSFMPV
     FVLGAAFGRL VGEIMATLFP NGILFDGMVY RILPGGYAVI GAAAMSGAVT HTVSTAVICF
     ELTGQISHIL PMMVAVILAN MVAQGLQPSL YDSIIQIKKL PYLPELGLGH ISKYNIFVED
     IMVKKVKFVS SRSTYRELKS LLQSTSLKTL PLVESEDSMI LLGSVETADL QVISDWWLSN
     ERRLLCQGRG LASRVSWESF AFVDEEAGEE TRDRSTSVQE EQNGPLPPPK PQEPLASHPV
     PNQGPPRALR NTFLHFFFPC ADRHSDAQAY RTPSLVDTMT PEEIKAWEEA ELDKQIDIEQ
     LRVDPSPFQL VEKTSLHKTH ALFSLLGISH AYITSIGKLV GVVALKELQK AIEGSTRSGV
     RLRPPLASFR EASRKAKKPA QAPSAPSSPK DGWKEGSRRD PNDGTGAGGA GAGGGTSGDG
     TPVAERGPVS PQTSPTSSLS IALSALRPTL KRKRDVEKQS EEEQI
//