ID A0A3B3R1U6_9TELE Unreviewed; 423 AA.
AC A0A3B3R1U6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Bone morphogenetic protein 7-like {ECO:0000313|Ensembl:ENSPKIP00000011890.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000011890.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000011890.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B3R1U6; -.
DR STRING; 1676925.ENSPKIP00000011890; -.
DR Ensembl; ENSPKIT00000023070.1; ENSPKIP00000011890.1; ENSPKIG00000018346.1.
DR GeneTree; ENSGT00940000156490; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048264; P:determination of ventral identity; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0021703; P:locus ceruleus development; IEA:Ensembl.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR CDD; cd19397; TGF_beta_BMP7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF135; BONE MORPHOGENETIC PROTEIN 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 303..423
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 277..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 48298 MW; 3874F11BA84F5F24 CRC64;
MSTVAAQSAA TLIFMWGYCA LCESFFTNFT FNEDLHYSFV ERRLRSQERR DMQREILSIL
GLPHRPRPHL HEKRSAAPLF MLDLYNVIST DGRQDLHPYK PVFTTQEPPI ASLQDSNFLS
NADMVMSFVD LVEHDRKSFP VRRHHREFRF NLSQIPEGGA VTAAEFRIYK DFVHEHFENE
TFRVTIYQVL QEHSNREPEL LLLDSRVTWA AEEGWLVFDI TATSKHWALH PGWDLVLQLA
LETMDGRSVN PKLAGLVGHS GPQNKQAFMV AFFKAAQSRP RRARSAGPKQ RGPGRPKVPK
NQEAPRATST AGNSSTDQKQ GCKKHELFVS FRDLGWQDWI IAPEGYAAYY CDGECAFPLN
SYMNATNHAI VQTLVHFVNP ETVPRPCCAP TQLHAISVLY FDDSSNVILK KYRNMVVRAC
GCH
//
